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PE-Labeled Monoclonal Anti-Human CTLA-4 Antibody, Mouse IgG2a (AS628) (0.03% Proclin)

COADS MS
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FABm043-01-200tests (50tests X 4)
$270.00
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Product Details

  • Clone

    AS628

  • Isotype

    Mouse IgG2a, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Immunogen

    Purified Human CTLA-4 Protein

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Specificity

    This product is a specific antibody specifically reacts with CTLA-4 protein.

  • Application

    Flow Cytometry (Detection the expression of CTLA-4 on Human cells).

  • Recommended Dilution

    1:20

  • Isotype Control

    The isotype control is sold separately; please refer to Cat. No. DNP-PM487 for product information.

  • Form

    Liquid

  • Formulation

    Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Shipping

    Liquid product is shipped at blue ice.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

    CTLA-4 FACS

    Flow cytometric analysis of THP-1 staining with PE-Labeled Monoclonal Anti-Human CTLA-4 Antibody, Mouse IgG2a (AS628) (Cat. No. FABm043-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in afinal volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QCtested).

    Protocol

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Background

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Recent Advances

 
Drug Development Progress
  • English Name：

    Cytotoxic T-Lymphocyte-Associated Antigen 4

  • Category：

  • Approved Drugs：

    5 Details

  • Drugs in Clinical Trials：

    65 Details

  • Highest Development Stage：

    Approved

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