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Human CEACAM-5 Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)

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Cat. No. / Size
Price
Qty
CE5-H5259-100ug
$360.00
CE5-H5259-1mg (500ug X 2)
$2380.00
ETA of in-stock products:2 business days
Sub-Total$ 0

Product Details

  • Synonyms

    CEACAM-5, CD66e, CEA, Meconium antigen 100

  • Source

    Human CEACAM-5, Llama IgG2b Fc Tag (CE5-H5259) is expressed from human 293 cells (HEK293). It contains AA Pro 593 - Ser 675 (Accession # P06731-1).

    Predicted N-terminus: Pro 593

    Request for sequence
  • Molecular Characterization

    CEACAM-5 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a llama IgG2b Fc tag at the C-terminus.

    The protein has a calculated MW of 36.7 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CEACAM-5 SDS-PAGE

    Human CEACAM-5, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    CEACAM-5 SEC-MALS

    The purity of Human CEACAM-5, Llama IgG2b Fc Tag (Cat. No. CE5-H5259) is more than 85% and the molecular weight of this protein is around 80-108 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CEACAM-5 ELISA

    Immobilized Human CEACAM-5, Llama IgG2b Fc Tag (Cat. No. CE5-H5259) at 1 μg/mL (100 μL/well) can bind Anti-CEACAM-5 (labetuzumab) Antibody, Human IgG1 with a linear range of 0.01-0.313 μg/mL (QC tested).

    Protocol

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Background

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is also Carcinoembryonic antigen (CEA), Meconium antigen 100, CD antigen CD66e, CEACAM5 belongs to the immunoglobulin superfamily and CEA family. CEACAM5 contains seven Ig-like (immunoglobulin-like) domains. CEACAM5 is homodimer protein which binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5 is cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is receptor for E.coli Dr adhesins.

Recent Advances

 
Drug Development Progress
  • English Name:

    Carcinoembryonic antigen related cell adhesion molecule 5

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    18 Details

  • Highest Development Stage:

    Phase 3 Clinical

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