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Product Details
Synonyms
Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor (MPR 300), Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor (IGF-II receptor), M6P/IGF2 receptor (M6P/IGF2R), CD222
Source
Human IGF-II R Protein, His Tag (IGR-H53H3) is expressed from CHO cells. It contains AA Met 1508 - Glu 1993 (Accession # P11717).
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.6 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human IGF-II R Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human IGF-II R Protein, His Tag (Cat. No. IGR-H53H3) is more than 90% and the molecular weight of this protein is around 50-75 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Biotinylated Human IGF-II, Avitag,Fc Tag (Cat. No. IG2-H82F9) at 5 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human IGF-II R Protein, His Tag (Cat. No. IGR-H53H3) with a linear range of 2-78 ng/mL (QC tested).
Protocol
Immobilized Human IGF-II R Protein, His Tag (Cat. No. IGR-H53H3) at 5 μg/mL (100 μL/well) can bind Human IGF-II, Fc Tag (Cat. No. IG2-H4260) with a linear range of 2-20 ng/mL (Routinely tested).
Protocol
Bioactivity-SPR
Biotinylated Human IGF-II, Avitag,Fc Tag (Cat. No. IG2-H82F9) captured on Protein A Chip can bind Human IGF-II R Protein, His Tag (Cat. No. IGR-H53H3) with an affinity constant of 189 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Insulin-like growth factor II receptor
- Category：
- Approved Drugs：
1 Details
- Drugs in Clinical Trials：
0 Details
- Highest Development Stage：
Approved
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