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Product Details
Synonyms
LAG3, CD223, FDC
Source
Cynomolgus LAG-3, Fc Tag (LA3-C5252) is expressed from human 293 cells (HEK293). It contains AA Ala 18 - His 449 (Accession # XP_005570011.1).
Predicted N-terminus: Ala 18
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 73.0 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>85% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Cynomolgus LAG-3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85%.
SEC-MALS
The purity of Cynomolgus LAG-3, Fc Tag (Cat. No. LA3-C5252) is more than 95% and the molecular weight of this protein is around 150-185 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Cynomolgus LAG-3, Fc Tag (Cat. No. LA3-C5252) at 2 μg/mL (100 μL/well) can bind Anti-Human LAG3 MAb, Human IgG1 with a linear range of 8-31 ng/mL (QC tested).
Protocol
Bioactivity-FACS
Flow Cytometry assay shows that Cynomolgus LAG-3, Fc Tag (Cat. No. LA3-C5252) can bind to daudi cell surface. The concentration of LAG-3 used is 1 μg/ml (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Lymphocyte activation gene 3 protein
- Category：
- Approved Drugs：
1 Details
- Drugs in Clinical Trials：
32 Details
- Highest Development Stage：
Approved
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