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Human NKp46 / NCR1 / CD335 Protein, Llama IgG2b Fc Tag, low endotoxin

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Cat. No. / Size
Price
Qty
NC1-H5255-100ug
$400.00
NC1-H5255-1mg (500ug X 2)
$2745.00
ETA of in-stock products:2 business days
Sub-Total$ 0

Product Details

  • Synonyms

    NCR1, LY94, CD335, NK-p46, hNKp46

  • Source

    Human NKp46, Llama IgG2b Fc Tag (NC1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asn 254 (Accession # O76036-6).

    Predicted N-terminus: Gln 22

    Request for sequence
  • Molecular Characterization

    NKp46 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a llama IgG2b Fc tag at the C-terminus.

    The protein has a calculated MW of 54.2 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    NKp46 SDS-PAGE

    Human NKp46, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity-ELISA

     NKp46 ELISA

    Immobilized Human NKp46, Llama IgG2b Fc Tag (Cat. No. NC1-H5255) at 1 μg/mL (100 μL/well) can bind Anti-NKP46 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

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Background

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Recent Advances

 
Drug Development Progress
  • English Name:

    Natural cytotoxicity triggering receptor 1

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    3 Details

  • Highest Development Stage:

    Phase 2 Clinical

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