Cynomolgus OSMR beta Protein, His Tag, low endotoxin (MALS verified)

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Cat. No. / Size
Price
Qty
OSR-C52H9-100ug
$395.00
OSR-C52H9-1mg (500ug X 2)
$2500.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB, OSMR, OSMRB

  • Source

    Cynomolgus OSMR, His Tag (OSR-C52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Ser 737 (Accession # A0A2K5UFW5-1).

    Predicted N-terminus: Glu 28

    Request for sequence
  • Molecular Characterization

    OSMR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 82.8 kDa. The protein migrates as 105-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    OSMR SDS-PAGE

    Cynomolgus OSMR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    OSMR SEC-MALS

    The purity of Cynomolgus OSMR, His Tag (Cat. No. OSR-C52H9) is more than 85% and the molecular weight of this protein is around 100-130 kDa verified by SEC-MALS.

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Background

Oncostatin-M-specific receptor subunit beta(OSMRB) alos know as Interleukin-31 receptor subunit beta (IL-31RB), is an alternative subunit (OSMRβ) for an OSM receptor complex (a heterodimer of gp130 and OSMRβ), that is activated by OSM but not by LIF. OSMR beta associates with the low affinity OSM·gp130 complex to form a high affinity heterodimeric receptor that is capable of transducing OSM-specific signaling events.

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Drug Development Progress
  • English Name:

    Oncostatin-M-specific receptor subunit beta

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Phase 2 Clinical

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