Human PTH1R / PTHR1 Protein, His Tag, low endotoxin (MALS verified)

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Cat. No. / Size
Price
Qty
PTR-H5222-100ug
$260.00
PTR-H5222-1mg (250ug X 4)
$1815.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    PTH1R, PTHR, PTHR1

  • Source

    Human PTH1R, His Tag (PTR-H5222) is expressed from human 293 cells (HEK293). It contains AA Asp 27 - Gly 188 (Accession # Q03431-1).

    Predicted N-terminus: Asp 27

    Request for sequence
  • Molecular Characterization

    PTH1R Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 19.6 kDa. The protein migrates as 27-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to different glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    PTH1R SDS-PAGE

    Human PTH1R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    PTH1R SEC-MALS

    The purity of Human PTH1R, His Tag (Cat. No. PTR-H5222) is more than 95% and the molecular weight of this protein is around 22-32 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     PTH1R ELISA

    Immobilized Human PTH1R, His Tag (Cat. No. PTR-H5222) at 5 μg/mL (100 μL/well) can bind PTH1R Recombinant Rabbit Monoclonal Antibody with a linear range of 0.01-0.313 ng/mL (QC tested).

    Protocol

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Background

Parathyroid hormone/parathyroid hormone-related peptide receptor is also known as Parathyroid hormone 1 receptor (PTH1R), PTHR1, PTH/PTHrP type I receptor (PTH/PTHr receptor), which belongs to the G-protein coupled receptor 2 family. PTH1R / PTHR1 is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Recent Advances

 
Drug Development Progress
  • English Name:

    Parathyroid hormone receptor

  • Category:

  • Approved Drugs:

    23 Details

  • Drugs in Clinical Trials:

    31 Details

  • Highest Development Stage:

    Approved

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