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Cynomolgus Tau Protein, Tag Free, low endotoxin

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Cat. No. / Size
Price
Qty
TAU-C5113-100ug
$360.00
TAU-C5113-1mg
$2615.00
ETA of in-stock products:2 business days
Sub-Total$ 0

Product Details

  • Synonyms

    DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU

  • Source

    Cynomolgus Tau Protein, Tag Free (TAU-C5113) is expressed from Yeast. It contains AA Ala 2 - Leu 776 (Accession # A0A2K5WB98-1).

    Request for sequence

  • Molecular Characterization

    Tau Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 82.9 kDa.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     Tau ELISA

    Immobilized Cynomolgus Tau Protein, Tag Free (Cat. No. TAU-C5113) at 5 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 0.1-8 ng/mL (QC tested).

    Protocol

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Background

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Recent Advances

 
Drug Development Progress
  • English Name:

    Microtubule-associated protein tau

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    46 Details

  • Highest Development Stage:

    Approved

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