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Product Details
Synonyms
TL1A, VEGI, TNFSF15
Source
Human TL1A Protein, Fc Tag (TLA-H5263) is expressed from human 293 cells (HEK293). It contains AA Val 84 - Leu 251 (Accession # O95150-1).
Predicted N-terminus: Pro
Molecular Characterization
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 85.1 kDa. The protein migrates as 95-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human TL1A Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) is more than 95% and the molecular weight of this protein is around 175-210 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human DR3 Protein, His Tag (Cat. No. TN5-H52H3) at 5 μg/mL (100 μL/well) can bind Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) with a linear range of 0.5-16 ng/mL (QC tested).
Protocol
Immobilized Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-TL1A Antibody, Human IgG1 with a linear range of 0.2-8 ng/mL (Routinely tested).
Protocol
Bioactivity-SPR
Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) immobilized on CM5 Chip can bind Human DcR3, Fc Tag (Cat. No. TNB-H5255) with an affinity constant of 0.621 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) immobilized on CM5 Chip can bind Human DR3 Protein, His Tag (Cat. No. TN5-H52H3) with an affinity constant of 1.05 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Tumor necrosis factor superfamily member 15
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
18 Details
- Highest Development Stage：
Phase 3 Clinical
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