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Product Details
Synonyms
TREM1, CD354
Source
Human TREM-1, Fc Tag (TR1-H5251) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Arg 200 (Accession # Q9NP99-1).
Predicted N-terminus: Ala 21
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 46.7 kDa. The protein migrates as 60-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human TREM-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
Bioactivity-ELISA
Immobilized Human TREM-1, Fc Tag (Cat. No. TR1-H5251) at 5 μg/mL (100 μL/well) can bind Recombinant Human PGLYRP1/PGRP-S Protein, CF with a linear range of 0.002-0.156 μg/mL (Routinely tested).
Protocol
Bioactivity-BLI
Loaded Human TREM-1, Fc Tag (Cat. No. TR1-H5251) on Protein A Biosensor, can bind Recombinant Human PGLYRP1/PGRP-S Protein, CF with an affinity constant of 18.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Triggering receptor expressed on myeloid cells 1
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
6 Details
- Highest Development Stage：
Phase 2 Clinical
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