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PE-Labeled Human uPAR / PLAUR Protein, His Tag (Site-specific conjugation)

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Cat. No. / Size
Price
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UPR-HP2H7-25tests
$360.00
UPR-HP2H7-200tests
$2245.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    uPAR, PLAUR, CD87, MO3

  • Source

    PE-Labeled Human uPAR, His Tag (UPR-HP2H7) is produced via site-specific conjugation of PE to Human uPAR, His Tag under optimal conditions with a proprietary technology. Human uPAR, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Arg 303 (Accession # Q03405-1).

    Predicted N-terminus: Leu 23

    Request for sequence

  • Molecular Characterization

    uPAR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 35.0 kDa.

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Application

    Please note that this product is NOT compatible to streptavidin detection system.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

     uPAR FACS

    5e5 of anti-uPAR CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human uPAR, His Tag (Cat. No. UPR-HP2H7) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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Background

Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

Recent Advances

 
Drug Development Progress
  • English Name:

    Urokinase plasminogen activator surface receptor

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    7 Details

  • Highest Development Stage:

    Phase 3 Clinical

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