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Your Position: Home > Protein > GDF-2 > GD2-H5211

Human GDF-2 Protein, Tag Free

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  • Synonym
    GDF-2,GDF2,BMP-9,BMP9
  • Source
    Human GDF-2, Tag Free(GD2-H5211) is expressed from human 293 cells (HEK293). It contains AA Ser 320 - Arg 429 (Accession # Q9UK05-1).
    Predicted N-terminus: Ser 320
  • Molecular Characterization
    GDF-2 Structure

    This protein carries no "tag".

    The protein has a calculated MW of 12.1 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in ACN, TFA in Water with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
GDF-2 SDS-PAGE

Human GDF-2, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA
 GDF-2 ELISA

Immobilized Human GDF-2, Tag Free (Cat. No. GD2-H5211) at 1 μg/mL (100 μL/well) can bind Human ALK-1, His Tag with a linear range of 2-16 ng/mL (QC tested).

  • Background
    Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.
  • Clinical and Translational Updates

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