Alexa Fluor™ 647-Labeled Human Alpha-synuclein Protein, His Tag

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Cat. No. / Size
Price
Qty
ALN-HA1H3-200ug
$840.00
ALN-HA1H3-1mg
$3150.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    SNCA, NACP, PARK1, alpha-Synuclein

  • Source

    Alexa Fluor 647-Labeled Human Alpha-synuclein Protein, His Tag (ALN-HA1H3) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1). It is the Alexa Fluor™ 647 labeled form of Human Alpha-Synuclein, His Tag (Cat. No. ALN-H52H8).

    Predicted N-terminus: Met 1

    Request for sequence
  • Molecular Characterization

    Alpha-Synuclein Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 16.3 kDa.

  • Conjugate

    AF647

    Excitation Wavelength: 640 nm

    Emission Wavelength: 672 nm

  • Labeling

    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with AF647 using standard chemical labeling method. The residual AF647 is removed by molecular sieve treatment during purification process.

  • Protein Ratio

    The AF647 to protein molar ratio is 2-4.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Background

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Recent Advances

 
Drug Development Progress
  • English Name:

    Synuclein alpha

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    25 Details

  • Highest Development Stage:

    Phase 3 Clinical

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