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Biotinylated Rhesus macaque CD89 / FCAR Protein, His,Avitag™ (MALS verified)

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Cat. No. / Size
Price
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CD9-R82E3-25ug
$360.00
CD9-R82E3-200ug
$1420.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    CD89, FCAR, IgA Fc receptor

  • Source

    Biotinylated Rhesus macaque CD89 Protein, His,Avitag (CD9-R82E3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asn 227 (Accession # F7H5K2-1).

    Predicted N-terminus: Gln 22

    Request for sequence
  • Molecular Characterization

    CD89 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 26.9 kDa. The protein migrates as 35-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD89 SDS-PAGE

    Biotinylated Rhesus macaque CD89 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD89 SEC-MALS

    The purity of Biotinylated Rhesus macaque CD89 Protein, His,Avitag (Cat. No. CD9-R82E3) is more than 90% and the molecular weight of this protein is around 40-60 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD89 ELISA

    Immobilized Human Anti-VP1 (NoV)-antibody-NORO-320, Human IgA2 | Human Kappa at 1 μg/mL (100 μL/well) can bind Biotinylated Rhesus macaque CD89 Protein, His,Avitag (Cat. No. CD9-R82E3) with a linear range of 0.08-2.5 μg/mL (QC tested).

    Protocol

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Background

CD89 (FcαRI), encoded by the FCAR gene, is an IgA-specific receptor primarily expressed on myeloid cells (e.g., neutrophils, monocytes/macrophages). It mediates immune defense functions by binding to the Fc region of IgA (with a preference for polymeric forms), facilitating phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and inflammation regulation. Its signaling relies on the ITAM motif of the FcRγ chain, enabling dual immunoregulatory roles in both activation and suppression. Clinically, CD89 is implicated in IgA nephropathy, pathogen immune evasion, and tumor immunity. Targeted therapies, such as the bispecific antibody MOR202, are under development for diseases like multiple myeloma, highlighting its therapeutic potential as a bridge between mucosal and systemic immunity.

Recent Advances

 
Drug Development Progress
  • English Name:

    IgA Fc receptor

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Phase 1 Clinical

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