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Mouse Fc epsilon RI alpha Protein, Fc Tag

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Cat. No. / Size
Price
Qty
FCA-M5253-100ug
$300.00
FCA-M5253-1mg (500ug X 2)
$1980.00
ETA of in-stock products:2 business days
Sub-Total$ 0

Product Details

  • Synonyms

    FCER1A, FCE1A, FcERI

  • Source

    Mouse Fc epsilon RI alpha Protein, Fc Tag (FCA-M5253) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Gln 204 (Accession # P20489).

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  • Molecular Characterization

    Fc epsilon RI alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 47.6 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 225 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

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  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Fc epsilon RI alpha SDS-PAGE

    Mouse Fc epsilon RI alpha Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Fc epsilon RI alpha ELISA

    Immobilized Mouse IgE Fc Protein, His Tag (Cat. No. IGE-M52H3) at 10 μg/mL (100 μL/well) can bind Mouse Fc epsilon RI alpha Protein, Fc Tag (Cat. No. FCA-M5253) with a linear range of 0.039-5 μg/mL (QC tested).

    Protocol

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Background

Fc epsilon RI alpha (FcεRIα) is the α-chain of the high-affinity IgE receptor (FcεRI), a critical mediator of type I hypersensitivity. As a transmembrane glycoprotein in the immunoglobulin superfamily, its extracellular domain specifically binds the Fc region of IgE. Mainly expressed on mast cells and basophils, FcεRIα cross-linking (by IgE-allergen complexes) triggers cell degranulation, releasing histamine and proinflammatory mediators—driving allergies, asthma, and anaphylaxis. It also participates in immune surveillance. Owing to its central role in allergic responses, FcεRIα is a key therapeutic target for anti-allergy agents.

Recent Advances

 
Drug Development Progress
  • English Name:

    IgE Fc receptor, alpha-subunit

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Approved

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