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Product Details
Synonyms
SIGLEC10, MGC126774, PRO940, Siglec10, SLG2
Source
Cynomolgus Siglec-10, His Tag (SI0-C52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - Ala 549 (Accession # A0A2K5WBX8-1).
Predicted N-terminus: Thr 17
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 60.2 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
The protein is designed as a dimer.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in 25 mM MES, 150 mM NaCl, 0.5 M Arginine, pH5.0 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Cynomolgus Siglec-10, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-MALS
The purity of Cynomolgus Siglec-10, His Tag (Cat. No. SI0-C52H5) is more than 90% and the molecular weight of this protein is around 145-160 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Cynomolgus Siglec-10, His Tag (Cat. No. SI0-C52H5) at 1 μg/mL (100 μL/well) on an Nickel Coated plate can bind Anti-Siglec-10 Antibody, Human IgG1 with a linear range of 0.009-0.156 μg/mL (QC tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Sialic acid-binding Ig-like lectin 10
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
3 Details
- Highest Development Stage：
Phase 3 Clinical
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