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Your Position: Home > RNF43

RNF43

Brief Information

Name:E3 ubiquitin-protein ligase RNF43
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
RN3-H5256 Human Human RNF43 Protein, Fc Tag (MALS verified)
RN3-H5256-structure
RN3-H5256-sds
ACRO Quality

Part of Bioactivity data

RN3-H5256-MALS-HPLC
RNF43 MALS images

The purity of Human RNF43, Fc Tag (Cat. No. RN3-H5256) is more than 85% and the molecular weight of this protein is around 100-115 kDa verified by SEC-MALS.

RN3-H5256-ELISA
RNF43 ELISA

Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 5 μg/mL (100 μL/well) can bind Human RNF43, Fc Tag (Cat. No. RN3-H5256) with a linear range of 2-20 ng/mL (QC tested).

Protocol

Synonym Name

RING finger protein 43，RING-type E3 ubiquitin transferase RNF43

Background

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)

Clinical and Translational Updates

    Clinical Drug Information

    Name Research Code Research Phase Company Indications Clinical Trials
    SZN-043 SZN-043; SZN-043双特异性融合蛋白; SZN-043 Bispecific Fusion Protein; SZN-043 (RSPO模拟物) Phase 1 Clinical Surrozen Inc Hepatitis, Alcoholic; Liver Cirrhosis Details

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