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Your Position: Home > FGF19


Brief Information

Name:Fibroblast growth factor 19
Target Synonym:FGF-19
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FG9-H51H3 Human Human FGF19 Protein, His Tag
FG9-H5253 Human Human FGF19 Protein, Fc Tag
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Part of Bioactivity data


Loaded Human FGF R4, Fc Tag (Cat. No. FG4-H5253) on Protein A Biosensor, can bind Human FGF19, His Tag (Cat. No. FG9-H51H3) with an affinity constant of 63.5 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).


Loaded Human FGF19, His Tag (Cat. No. FG9-H51H3) on HIS1K Biosensor, can bind Human FGF R4, Fc Tag (Cat. No. FG4-H5253) with an affinity constant of 16.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Customer Reviews

Synonym Name

FGF19/FGF-19/Fibroblast growth factor 19


Fibroblast growth factor (FGF)19 is the first members of a new subfamily of FGFs and could act as hormones. During fetal life, FGF15/19 is involved in organogenesis, affecting the development of the ear, eye, heart, and brain. FGFs–FGFRs are involved in regulation of many biological processes such as embryonic development, cell proliferation, differentiation, and tissue repair. The dysregulation of FGF–FGFR  was observed in different types of diseases, disorders, and cancers. Notably, aberrant expression of FGF19/FGFR4 contributes to Hepatocellular Carcinoma progression.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Aldafermin NGM-282; M70; M-70; NGM282 Phase 2 Clinical Ngm Biopharmaceuticals Inc Liver Cirrhosis, Biliary; Constipation; Irritable Bowel Syndrome; Metabolic Dysfunction-Associated Steatotic Liver Disease; Renal Insufficiency; Bile acid malabsorption (BAM); Fibrosis; Cholangitis, Sclerosing; Diarrhea; Hepatic Insufficiency; Malabsorption Syndromes; Diabetes Mellitus Details

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