0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > CRTAM

CRTAM

CRTAM Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CRM-C5255 Cynomolgus Cynomolgus CRTAM Protein, Fc Tag
CRM-C5255-structure
CRM-C5255-sds

CRTAM Molecule Synonym Name

CRTAM

CRTAM Molecule Background

Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.

CRTAM References

This web search service is supported by Google Inc.

totop