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Your Position: Home > CRTAM

CRTAM

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Cat. No. Species Product Description Structure Purity Feature
CRM-H52H3 Human Human CRTAM Protein, His Tag
CRM-H52H3-structure
CRM-H52H3-sds
CRM-C5255 Cynomolgus Cynomolgus CRTAM Protein, Fc Tag
CRM-C5255-structure
CRM-C5255-sds
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Part of Bioactivity data

CRM-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CRTAM, His Tag (Cat. No. CRM-H52H3) on AR2G Biosensor, can bind Human CADM1, His Tag (Cat. No. CA1-H5225) with an affinity constant of 51.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
CRM-C5255-BLI
CRTAM BLI

Loaded Cynomolgus CRTAM, Fc Tag (Cat. No. CRM-C5255) on Protein A Biosensor, can bind Human CADM1, His Tag (Cat. No. CA1-H5225) with an affinity constant of 37.7 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

CRTAM,CD355

Background

Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.

Clinical and Translational Updates

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