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IL-1RL1

Brief Information

Name:Interleukin-1 receptor-like 1
Target Synonym:ST2,IL1RL1,Protein ST2,DER4,T1,Interleukin 1 Receptor Like 1,Homolog Of Mouse Growth Stimulation-Expressed,Interleukin 1 Receptor-Related Protein,Growth Stimulation-Expressed,FIT-1,IL33R,ST2L,ST2V,Interleukin-1 Receptor-Like 1 Protein,EC:3.2.2.6,Interleuk
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:NDA/BLA

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
IL1-H5250 Human Human IL-1RL1 / ST2 Protein, Fc Tag
IL1-H5250-structure
IL1-H5250-sds
IL1-H5250-elisa_1
IL1-H5229 Human Human IL-1RL1 / ST2 Protein, His Tag
IL1-H5229-structure
IL1-H5229-sds
IL1-H5229-elisa_1

Part of Bioactivity data

IL1-H5229-ELISA
Human IL-1RL1, His TagHuman IL-1RL1, His Tag (Cat. No. IL1-H5229) ELISA bioactivity

Immobilized Human IL-1RL1, His Tag (Cat. No. IL1-H5229) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-33, His,Avitag (Cat. No. IL3-H82H5) with a linear range of 0.02-0.313 μg/mL (QC tested).

IL1-H5250-ELISA
Human IL-1RL1, Fc TagHuman IL-1RL1, Fc Tag (Cat. No. IL1-H5250) ELISA bioactivity

Immobilized Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) at 5 μg/mL (100 μL/well) can bind Human IL-33, His Tag (Cat. No. IL3-H52H7) with a linear range of 5-40 ng/mL (QC tested).

Synonym Name

IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

Background

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Astegolimab AMG-282; RG-6149; RO-7187807 Phase 2 Clinical F. Hoffmann-La Roche Ltd, Amgen Inc Coronavirus Disease 2019 (COVID-19); Sinusitis; Asthma; Dermatitis, Atopic Details
Recombinant humanized anti-ST2 monoclonal antibody 9MW1911 Phase 1 Clinical Mabwell (Shanghai) Bioscience Co Ltd Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi) REGN-3500; SAR-440340 Phase 3 Clinical Regeneron Pharmaceuticals Inc, Sanofi Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
MEDI-3506 MEDI-3506 Phase 2 Clinical Medimmune Diabetic Nephropathies; Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic; Bronchitis, Chronic Details

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