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Your Position: Home > IL-1RL1

IL-1RL1

Brief Information

Name:Interleukin-1 receptor-like 1
Target Synonym:ST2,IL1RL1,Protein ST2,DER4,T1,Interleukin 1 Receptor Like 1,Homolog Of Mouse Growth Stimulation-Expressed,Interleukin 1 Receptor-Related Protein,Growth Stimulation-Expressed,FIT-1,IL33R,ST2L,ST2V,Interleukin-1 Receptor-Like 1 Protein,EC:3.2.2.6,Interleukin-1 Receptor-Like 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:NDA/BLA

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Part of Bioactivity data

IL1-H5250-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) on Protein A Biosensor, can bind with Biotinylated Human IL-33, His,Avitag (Cat. No. IL3-H82H5) an affinity constant of 1.81 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL1-H82E9-ELISA
Biotinylated Human IL-1RL1, His,Avitag™Biotinylated Human IL-1RL1, His,Avitag™ (Cat. No. IL1-H82E9) ELISA bioactivity

Immobilized Human IL-33, His Tag (Cat. No. IL3-H52H7) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-1RL1, His,Avitag (Cat. No. IL1-H82E9) with a linear range of 0.3-10 ng/mL (QC tested).

Synonym Name

IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

Background

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant humanized anti-ST2 monoclonal antibody 9MW1911; 9-MW1911; 9MW-1911; 9-MW-1911 Phase 1 Clinical Mabwell (Shanghai) Bioscience Co Ltd Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Astegolimab AMG-282; RG-6149; RO-7187807 Phase 2 Clinical Amgen Inc, F. Hoffmann-La Roche Ltd Coronavirus Disease 2019 (COVID-19); Asthma; Sinusitis; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Tozorakimab MEDI-3506 Phase 3 Clinical Medimmune Asthma; Diabetic Nephropathies; Pulmonary Disease, Chronic Obstructive; Bronchitis, Chronic; Dermatitis, Atopic Details

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