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TREM2

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Cat. No. Species Product Description Structure Purity Feature
TR2-M52H3 Mouse Mouse TREM2 Protein, His, Tag
TR2-M52H3-structure
TR2-M52H3-sds
TR2-H52H5 Human Human TREM2 Protein, His, Tag
TR2-H52H5-structure
TR2-H52H5-sds
TR2-H82E7 Human Biotinylated Human TREM2 Protein, His,Avitag™
TR2-H82E7-structure
TR2-H82E7-sds

TREM2 Part of Bioactivity data

TR2-H82E7-ELISA
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human TREM2, His,Avitag (Cat. No. TR2-H82E7) on SA Biosensor, can bind Human Apolipoprotein E, His Tag (Cat. No. APE-H5246) with an affinity constant of 37.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

TREM2 Molecule Synonym Name

Triggering receptor expressed on myeloid cells 2/TREM2/TREM-2

TREM2 Molecule Background

Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.

TREM2 References

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