Integrin alpha X beta 2
Target Synonym:Integrin alphaXbeta2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:
Integrin alpha X beta 2, ITGAX&ITGB2, CD11C, CD18
The integrin αXβ2 takes a key role in host defense and functions as a receptor for the complement C3 cleavage product iC3b, fibrinogen, denatured proteins, and intercellular adhesion molecule (ICAM)-1. Integrin αXβ2 αXβ2 has a unique cellular distribution with expression on monocytes, macrophages, and the CD8− subsets of dendritic cells and involves in priming and regulation of the immune response.
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