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Integrin alpha E beta 7

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Cat. No. Species Product Description Structure Purity Feature
IT7-H52W7 Human Human Integrin alpha E beta 7 (ITGAE&ITGB7) Heterodimer Protein, His Tag&Tag Free
IT7-H52W7-structure
IT7-H52W7-sds

Integrin alpha E beta 7 Molecule Synonym Name

Integrin alpha E beta 7,ITGAE&ITGB7,HML-1,CD103,ITGAE&B7

Integrin alpha E beta 7 Molecule Background

Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body. The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.

Integrin alpha E beta 7 References

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