Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Integrin alpha 2 beta 1

Integrin alpha 2 beta 1

Brief Information

Name:Integrin alpha2/beta1
Target Synonym:Integrin alpha2beta1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
IT1-C52W5 Cynomolgus Cynomolgus Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT1-C52W5-structure
IT1-C52W5-sds
IT1-R52W9 Rat Rat Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein, His Tag&Tag Free
IT1-R52W9-structure
IT1-R52W9-sds
IT1-M52W3 Mouse Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT1-M52W3-structure
IT1-M52W3-sds
IT1-H52W6 Human Human Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein, His Tag&Tag Free
IT1-H52W6-structure
IT1-H52W6-sds
ACRO Quality

Part of Bioactivity data

IT1-R52W9-ELISA
Integrin alpha 2 beta 1 ELISA

Immobilized Native Human Collagen IV Protein at 2 μg/mL (100 μL/well) can bind Rat ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-R52W9) with a linear range of 0.039-0.625 μg/mL (QC tested).

Protocol
IT1-C52W5-MALS-HPLC
Integrin alpha 2 beta 1 MALS images

The purity of Cynomolgus ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-C52W5) is more than 90% and the molecular weight of this protein is around 210-260 kDa verified by SEC-MALS.

Synonym Name

Integrin alpha 2 beta 1,ITGA2 & ITGB1

Background

Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Risuteganib ALG-1001; AM011; AM-011(Allegro Ophthalmics) Phase 1 Clinical Allegro Ophthalmics Llc Diabetic macular oedema; Geographic Atrophy; Diabetic Retinopathy; Macular Degeneration Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap