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Your Position: Home > Integrin alpha 2 beta 1

Integrin alpha 2 beta 1

Brief Information

Name:Integrin alpha2/beta1
Target Synonym:Integrin alpha2beta1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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ACRO Quality

Part of Bioactivity data

 Integrin alpha 2 beta 1 ELISA

Immobilized Human Collagen IV at 2 μg/mL (100 μL/well) can bind Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W3) with a linear range of 0.02-0.625 μg/mL (QC tested).

Integrin alpha 2 beta 1 MALS images

The purity of Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W3) is more than 90% and the molecular weight of this protein is around 210-240 kDa verified by SEC-MALS.

Synonym Name

Integrin alpha 2 beta 1,ITGA2 & ITGB1


Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Risuteganib ALG-1001; AM011; AM-011(Allegro Ophthalmics) Phase 1 Clinical Allegro Ophthalmics Llc Diabetic macular oedema; Geographic Atrophy; Macular Degeneration; Diabetic Retinopathy Details

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