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Integrin alpha 2 beta 1

Brief Information

Name:Integrin alpha2/beta1
Target Synonym:Integrin alpha2beta1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IT1-H52W6-ELISA
Human ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag FreeHuman ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W6) ELISA bioactivity

Immobilized Human Collagen I protein at 2 μg/mL (100 μL/well) can bind Human ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W6) with a linear range of 0.078-1.25 μg/mL (QC tested).

IT1-M52W3-MALS-HPLC
Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. ) MALS images

The purity of Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free(Cat. No. IT1-M52W3) was more than 90% and the molecular weight of this protein is around 210-240 kDa verified by SEC-MALS.

Bioactivity-ELISA
Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag FreeMouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W3) ELISA bioactivity

Immobilized Human Collagen IV at 2 μg/mL (100 μL/well) can bind Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W3) with a linear range of 0.02-0.625 μg/mL (QC tested).

Synonym Name

Integrin alpha 2 beta 1,ITGA2 & ITGB1

Background

Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Risuteganib ALG-1001 Phase 2 Clinical Allegro Ophthalmics Retinal Diseases; Diabetic macular oedema; Diabetic Retinopathy; Macular Degeneration Details

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