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Your Position: Home > Immune Checkpoint Proteins > B7-H6 > Cynomolgus B7-H6 / NCR3LG1 Protein

Cynomolgus B7-H6 / NCR3LG1 Protein

  • Synonym
    B7-H6,NCR3LG1,B7 Homolog 6
  • Source
    Cynomolgus B7-H6 (B76-C52Ha) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Asp 259 (Accession # XP_005578557.1).
    Predicted N-terminus: Asp 25
  • Molecular Characterization
    B7-H6(Asp 25 - Asp 259) XP_005578557.1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus B7-H6 (Cat. No. B76-C52Ha) SDS-PAGE gel

Cynomolgus B7-H6 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity
Cynomolgus B7-H6Cynomolgus B7-H6 (Cat. No. B76-C52Ha) ELISA bioactivity

Immobilized Human NKp30, Fc Tag (Cat. No. NC3-H5259) at 5 μg/mL (100 μL/well) can bind Cynomolgus B7-H6 (Cat. No. B76-C52Ha) with a linear range of 0.625-5 μg/mL (QC tested).

  • Background
    The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $300.00

Price(USD) : $1980.00

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