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Your Position: Home > All Other Proteins > HMGB1 > HM1-M52H6

Mouse HMGB1 Protein, His Tag

  • Synonym
    HMGB1,HMG1,HMG3,SBP-1
  • Source
    Mouse HMGB1, His Tag (HM1-M52H6) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Glu 215 (Accession # P63158-1).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    Online(Met 1 - Glu 215) P63158-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 26.8 kDa. The protein migrates as 33 kDa and 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Mouse HMGB1, His Tag (Cat. No. HM1-M52H6) SDS-PAGE gel

Mouse HMGB1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

  • Background
    High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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