Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM130) (Trehalose free)

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S1N-M13A1-100ug
$450.00
In Stock - Delivery in 1-2 business days
S1N-M13A1-1mg
$3,255.00
In Stock - Delivery in 1-2 business days
S1N-M13A1-10mg (5mg X 2)
$29,610.00
In Stock - Delivery in 2-3 weeks
S1N-M13A1-100mg
$296,125.00
In Stock - Delivery in 2-3 weeks
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  • Product Details
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Source

Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM130) (S1N-M13A1) is a chimeric monoclonal antibody recombinantly expressed in HEK293 cells, which combines the variable regions of a mouse monoclonal antibody with human IgG1 constant domains. The variable regions was obtained from a mouse immunized with purified recombinant SARS-CoV-2 Spike S1 Protein.

Antibody Type

Recombinant Monoclonal

Clone

AM130

Isotype

Human IgG1, Kappa

Host Species

Mouse

Reactivity

Virus

Specificity

This product can recognize SARS-CoV-2 and SARS-CoV Spike protein RBD domain. No cross-reactivity is detected with Spike protein RBD domain of other coronaviruses, including MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1.

Application
Application
Recommended Use / Performance
ELISA
0.2-2 μg/mL
Purification

Protein A purified.

Aggregation

Less than 10%, as determined by SEC-MALS.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Liquid

Formulation

Supplied a 0.22 μm-filtered solution in PBS (pH 7.4).

Please contact us for customized product forms or formulations.

Storage

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • For long term storage, the product is stable for up to 3 years at -70°C from date of receipt;
  • For short term storage, the product is stable for up to 12 months at 2-8°C from date of receipt.
Notices

Product Specific Notices: For research use only.

Background

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.