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Your Position: Home > Immune Checkpoint Proteins > TREM2 > TR2-M52H3

Mouse TREM2 Protein, His, Tag

  • Synonym
    Triggering receptor expressed on myeloid cells 2/TREM2/TREM-2
  • Source
    Mouse TREM2, His, Tag (TR2-M52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Ser 171 (Accession # Q99NH8-1).
    Predicted N-terminus: Leu 19
  • Molecular Characterization
    Online(Leu 19 - Ser 171) Q99NH8-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 18.7 kDa. The protein migrates as 25-45 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Mouse TREM2, His, Tag (Cat. No. TR2-M52H3) SDS-PAGE gel

Mouse TREM2, His, Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

  • Background
    Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.
  • References
    • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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    Price(USD) : $350.00

    Price(USD) : $2310.00

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