Human LBP / Lipopolysaccharide-binding (I465F) Protein, His Tag

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Cat. No. / Size
Price
Qty
LBP-H52H5-100ug
$325.00
LBP-H52H5-1mg (250ug X 4)
$2040.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Lipopolysaccharide-binding protein, LBP

  • Source

    Human Lipopolysaccharide-binding (I465F) Protein, His Tag (LBP-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Val 481 (Accession # P18428-1 (I465F)).

    Predicted N-terminus: Ala 26

    Request for sequence
  • Molecular Characterization

    Lipopolysaccharide-binding protein / LBP Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 52.8 kDa. The protein migrates as 62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Lipopolysaccharide-binding protein / LBP SDS-PAGE

    Human Lipopolysaccharide-binding (I465F) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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Background

Lipopolysaccharide-binding protein (LBP),a member of the BPI/LBP/Plunc superfamily, BPI/LBP family, is detected in blood serum. LBP plays a role in the innate immune response. Alao,LBP can bind to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and act as an affinity enhancer for CD14, facilitating its association with LPS. Furthermore, LBP is able to promote the release of cytokines in response to bacterial lipopolysaccharide.

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