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MMAE

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Part of Bioactivity data

MME-MY2209-ELISA
 MMAE ELISA

Immobilized Disitamab Vedotin (RC48) at 0.2 μg/mL (100 μL/well) can bind Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1H09) (Cat. No. MME-MY2209) with a linear range of 0.06-1 ng/mL (QC tested).

MME-MY2198a-ELISA
 MMAE ELISA

Immobilized Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1H05) (Cat. No. MME-MY2198a) at 5 μg/mL, add Disitamab Vedotin (RC48) in the 100% Human Serum and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

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Background

Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. Anti-MMAE antibody is a Mouse monoclonal antibody. This antibody has been shown to work in applications such as: PK, PD, Immunoassay and ELISA.

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