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Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases.
Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. Explore our pre-seeded PFFs to use in your research.
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells.
Partnering with Diagnostic Biochips, we now provide solutions for in vivo electrophysiology recordings, including high-quality multi-channel electrodes and other products to facilitate high-quality, efficient analysis of neural circuit structure and function.
Protein markers are an essential component in biological research and drug development. Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency.
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. We offer a wide array of products pre-conjugated with streptavidin to support your research as well as biotinylated proteins.
Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. Explore our isotype controls for your research.
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. Explore our comprehensive collection of recombinant Fc receptor proteins!
We committed to accelerating the research, development, approval, and commercialization of infectious disease vaccines. With this idea, ViruStop is specially designed for virus research!
Interleukins (ILs) is a term that describes a group of secreted molecules produced by leukocytes that act on a variety of cells. Generally, ILs are classified as cytokines, but are also a member of the lymphokines family. ILs have diverse biological functions; not only is it involved in regulating immune response such as promoting the information transmission, activation and regulation of immune cells, but also is widely involved in regulating the physiological and pathological processes of the body such as autoimmune, inflammatory and tumor diseases. Based on the structural homology of cytokines, interleukins are divided into several protein families, such as IL-1, IL-2, IL-6, IL-10, IL-12, and IL-17 families.
It is worth noting that, the interleukin family has emerged as a significant drug target, many of which are already on the market and even occupy a significant market share of drugs for similar diseases.
High purity and high structural homogeneity verified by SDS-PAGE and SEC-MALS
Biotinylated Human IL-1 RAcP, His,Avitag (Cat. No. ILP-H82E5) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%. As verified by SEC-MALS, the purity is more than 90% and the molecular weight of this protein is around 50-68 kDa.
Human IL-2RB&IL-2RA&IL-2RG, Fc Tag&Fc Tag (Cat. No. ILG-H5257) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%. As verified by SEC-MALS, the purity is more than 90% and the molecular weight of this protein is around 160-190 kDa.
High biological activity verified by ELISA
Immobilized Mouse IL-2, His Tag (Cat. No. IL2-M52H3) at 5 μg/mL (100 μL/well) can bind Mouse IL-2RB&IL-2RA&IL-2RG, Fc Tag&Fc Tag (Cat. No. ILG-M5253) with a linear range of 0.8-3 ng/mL (QC tested).
Immobilized Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) with a linear range of 0.1-2 ng/mL (Routinely tested).
Affinity verified by SPR and BLI
Human IL-31, His Tag (Cat. No. IL1-H5247) capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag (Cat. No. ILA-H5256) with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Human IL-13 R alpha 1 Protein, His Tag (Cat. No. IL1-H5224) captured on CM5 chip via anti-His antibody can bind Human IL-13 with an affinity constant of 16 nM as determined in a SPR assay (Biacore T200) (QC tested).
Loaded Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) on SA Biosensor, can bind Human IL-6 R alpha, His Tag (Cat. No. ILR-H4223) with an affinity constant of 45.9 nM as determined in BLI assay (ForteBio Octet Red96e).
Loaded Biotinylated Human IL17A, His,Avitag (Cat. No. ILA-H82Q1) on SA Biosensor, can bind Human IL-17 RA, His Tag (Cat. No. ILA-H5222) with an affinity constant of 18.8 nM as determined in BLI assay (ForteBio Octet Red96e).
References
1. Chung S H, Ye X Q, Iwakura Y. Interleukin-17 family members in health and disease[J]. International immunology, 2021, 33(12): 723-729. https://doi.org/10.1093/intimm/dxab075.
2. Wojno E D T, Hunter C A, Stumhofer J S. The immunobiology of the interleukin-12 family: room for discovery[J]. Immunity, 2019, 50(4): 851-870. https://doi.org/10.1016/j.immuni.2019.03.011.
3. Rose-John S. Interleukin-6 family cytokines[J]. Cold Spring Harbor perspectives in biology, 2018, 10(2): a028415. https://doi.org/10.1101/cshperspect.a028415.
4. Netea M G, van de Veerdonk F L, van der Meer J W M, et al. Inflammasome-independent regulation of IL-1-family cytokines[J]. Annual review of immunology, 2015, 33: 49-77. https://doi.org/10.1146/annurev-immunol-032414-112306.
5. Zdanov A. Structural analysis of cytokines comprising the IL-10 family[J]. Cytokine & growth factor reviews, 2010, 21(5): 325-330.doi:10.1016/j.cytogfr.2010.08.003.
6. Dumont F J. Interleukin-2 family cytokines: potential for therapeutic immmunoregulation[J]. Expert Opinion on Therapeutic Patents, 2005, 15(5): 521-554. https://doi.org/10.1517/13543776.15.5.521.
7. Fickenscher H, Hör S, Küpers H, et al. The interleukin-10 family of cytokines[J]. Trends in immunology, 2002, 23(2): 89-96. https://doi.org/10.1016/S1471-4906(01)02149-4.
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