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Integrin alpha V beta 5 / ITGAVB5 Molecule  


Integrin alpha V beta 5 / ITGAVB5 Molecule Synonym Name

Integrin alpha V beta 5,ITGAVB5,ITGAV & ITGB5

Integrin alpha V beta 5 / ITGAVB5 Protein Products

Cat No Species Product Description
IT5-H52W5HumanHuman Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein

Integrin alpha V beta 5 / ITGAVB5 Molecule Background

Integrin alpha V beta 5 (ITGAV & ITGB5 or ITGAVB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAVB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAVB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

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