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Your Position: Home > Antigens & Antibodies for Diagnostic Kit Development

Antigens & Antibodies for Diagnostic Kit Development

   Committed to high sensitivity & specificity

 Antigens & Antibodies for Diagnostic kit development – Dedicated to high sensitivity & specificity
Background

The current methods of detecting SARS-CoV-2 infection include nucleic acid detections, antibody detections, and antigen detections. Compared to nucleic acid detections, antibody detections and antigen detections are faster and more convenient. Therefore, they are suitable for scenarios such as rapid screening and instant detection.

The sensitivity and specificity of the serological diagnostic kits are significantly affected by the quality of antigen and antibody reagents. To better support the development of the diagnostic kits, ACROBiosystems has developed a serial of high-quality antigen and antibody reagents. Furthermore, several in vitro diagnostics companies are using ACRO's reagents to develop COVID-19 serological diagnostics products. Among them, Babson Diagnostics, a US diagnostics company, successfully obtained the Emergency Use Authority from FDA and launched their chemiluminescent COVID-19 antibody detection kit employing ACRO's biotin-labeled S1 protein.

Matched antibody pairs

ACROBiosystems has launched matched antibody pairs specifically designed for diagnostic kits. The sensitivity of the ELISA assays using our matched antibody pairs can reach 12 pg/mL, which is very impressive. What's more, the affinity of these antibodies towards their antigens can be as low as 0.01 nM level. Thus, they are perfect for different antigen detection assays, such as chemiluminescent immunoassay, ELISA, gold immunochromatography assay, etc.

Product list

We now offer free samples to the researchers working on the diagnostic kit development. Get it now!

CategoryCat. No.SpeciesProduct Description
Nucleocapsid protein  Antibody PairNUN-S41A1HumanAnti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (recommended as capture antibody when applied for ELISA)Inquiry
NUN-S42A1HumanAnti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (recommended as detection antibody when applied for ELISA)Inquiry
Nucleocapsid protein Antibody PairNUN-S46MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb (recommended as capture antibody when applied for ELISA)Inquiry
NUN-S47MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb (recommended as detection antibody when applied for ELISA)Inquiry
S1 protein Antibody PairS1N-M12A1MouseAnti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb (recommended as capture antibody when applied for ELISA)Inquiry
S1N-M13A1MouseAnti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb (recommended as detection antibody when applied for ELISA)Inquiry

>>>  If you have any bulk order inquiry, please feel free to click here.

Assay data

High sensitivity of 12 pg/mL (ELISA assay)

Fig 1 Immobilized Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S46) at 4 μg/mL, add increasing concentrations of SARS-CoV-2 Nucleocapsid protein and then add Biotinylated Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S47). Detection was performed using HRP-conjugated streptavidin with sensitivity of 12 pg/mL.

Super affinity of 0.01 nM level(BLI assay)

Fig 2 Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse MAb(Cat. No. NUN-S47) can bind SARS-CoV-2 Nucleocapsid Protein(Cat. No. NUN-C5227) with an affinity constant of 24.7pM determined in BLI assay (ForteBio Octet Red96e)


Specific binding to SARS-CoV-2 Nucleocapsid protein

Fig 3 Demonstration of the specificity of Anti-SARS-CoV-2 N antibody (Cat. No. NUN-S42) to the Nucleocapsid protein.

High batch-to batch consistency

Fig 4 Demonstration of the Batch to Batch Consistency of Anti-SARS-CoV-2 Spike S1 Antibody, Chimeric Mab (Cat. No. S1N-M122) to the S1 protein.

Antigens

ACROBiosystems has designed Spike and Nucleocapsid antigens specifically for diagnostic kits development. The antigens are customizable and bulk order is available. They are perfect for different antibody detection methods, such as chemiluminescent immunoassay, ELISA, gold immunochromatography assay, etc.

Product list

MoleculeCat. No.SpeciesProduct Description
S proteinSPN-C52H2HEK293SARS-CoV-2 (COVID-19) S protein (R683A, R685A) , His Tag, active trimer (MALS verified)Inquiry
S1 protienS1N-C52H2HEK293SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified)Inquiry
S1N-C82E8HEK293Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified)Inquiry
S2 proteinS2N-C52H2HEK293SARS-CoV-2 (COVID-19) S2 protein, His TagInquiry
RBD proteinSPD-C52H1HEK293SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)*Inquiry
SPD-C52H2HEK293SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)*Inquiry
SPD-C5251HEK293SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc TagInquiry
SPD-C82E9HEK293Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified)Inquiry
Nucleocapsid proteinNUN-C5221HEK293SARS-CoV-2 (COVID-19) Nucleocapsid protein, His TagInquiry
NUN-C51H2E.coliSARS-CoV-2 (COVID-19) Nucleocapsid protein, His TagInquiry
NUN-C81Q8E.coliBiotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™Inquiry
Envelope ProteinENN-C5128HEK293SARS-CoV-2 (COVID-19) Envelope protein, GST,His TagInquiry

*RBD proteins, SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified) with Cat.No. SPD-C52H1 and SPD-C52H2 were expressed in different sequence regions.

>>>  If you have any bulk order inquiry, please feel free to click here.

>>>  If you have any custom inquiries or suggestions for SARS-CoV-2 (COVID-19) related products, please click here.

Assay data

High sensitivity of 0.02 ng/mL (ELISA assay)

Fig.5 Immobilized SARS-CoV-2 Nucleocapsid protein, His Tag at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 NP Antibody, Rabbit MAb (CLN27) with a linear range of 0.02-0.3 ng/mL.

>>> All SARS-CoV-2 related products

>>> SARS-CoV-2 related kits

>>> Pre-coupling beads

>>> Any custom requests, suggestions or feedback are welcome.Click here.

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