Neuraminidase (NA) Protein

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Neuraminidase (NA)

Brief Information

Name:Neuraminidase
Target Synonym:Neuraminidase

Number of Launched Drugs:4
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved


NEE-V5243	Influenza	Influenza A[A/swine/Jiangsu/J004/2018(H1N1)] Neuraminidase (NA) Protein, His Tag
H54-V5247	Influenza	Influenza A [A/Thailand/1(KAN-1)/2004 (H5N1)] Neuraminidase (NA) Protein, His Tag

Cat. No.

Species

Product Description

Structure

Purity

Feature

NEE-V5243

Influenza

Influenza A[A/swine/Jiangsu/J004/2018(H1N1)] Neuraminidase (NA) Protein, His Tag

H54-V5247

Influenza

Influenza A [A/Thailand/1(KAN-1)/2004 (H5N1)] Neuraminidase (NA) Protein, His Tag

Synonym Name

NA,Neuraminidase

Background

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

Clinical and Translational Updates

Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Peramivir Hydrate	JNJ-2; BCX-1812; S-021812; RWJ-270201	Approved	Biocryst Pharmaceuticals	力纬, Alpivab, Rapivab, Rapiacta, Peramiflu	United States	Influenza, Human	Biocryst Pharmaceuticals Inc	2010-01-13	Cough; Headache; Myalgia; Musculoskeletal Pain; Fatigue; Influenza, Human; Fever; Arthralgia; Nasal Obstruction; Pharyngitis	Details
Oseltamivir Phosphate	GS-4104; EN-241104; RO-640796; Ro-64-0796; GS-4104-002; GS-4104/002; RO-640796/002	Approved	F. Hoffmann-La Roche Ltd	达菲, Tamiflu, Hanmi Flu	EU	Influenza, Human	Roche Registration Gmbh	1999-09-21	Influenza, Human; Kidney Failure, Chronic	Details
Zanamivir	GG-167; GR-121167; GR-121167X; 4-Guanidino-Neu5Ac2en	Approved	Glaxosmithkline Plc	依乐韦, Relenza	EU	Influenza, Human	Glaxosmithkline Trading Services Ltd	1999-07-26	Orthomyxoviridae Infections; Influenza, Human	Details
Laninamivir Octanoate Hydrate	CS-8958; R-118958	Approved	Daiichi Sankyo Co Ltd	Inavir	Japan	Influenza B virus infection; Influenza A virus infections	Daiichi Sankyo Co Ltd	2010-09-10	Influenza A virus infections; Influenza, Human; Asthma; Influenza B virus infection	Details

Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
Oseltamivir/Pimodivir		Phase 1 Clinical	Johnson & Johnson	Influenza A virus infections	Details
HNC042	HNC-042	Phase 1 Clinical	Guangzhou Henovcom Bioscience Co Ltd	Influenza A virus infections; Influenza, Human; Influenza B virus infection	Details