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Your Position: Home > Neuraminidase (NA)

Neuraminidase (NA)

Brief Information

Name:Neuraminidase
Target Synonym:Neuraminidase
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
NEE-V524m Influenza Influenza A [Wisconsin/67/2022(H1N1)] Neuraminidase (NA) Protein, His Tag
NEE-V524m-sds
HA1-V5245 Influenza Influenza A [A/Thailand/1(KAN-1)/2004(H5N1)] Neuraminidase (NA) Protein, His Tag
HA1-V5245-structure
HA1-V5245-sds
NEE-V524k Influenza Influenza A [Wisconsin/588/2019(H1N1)] Neuraminidase (NA) Protein, His Tag
NEE-V524k-structure
NEE-V524k-sds
NEE-V524h Influenza Influenza A [Guangdong/18SF020(H5N6)] Neuraminidase (NA) Protein, His Tag (MALS & SPR verified)
NEE-V524h-structure
NEE-V524h-sds
NEE-V524e Influenza Influenza A [Victoria/2570/2019(H1N1)] Neuraminidase (NA) Protein, His Tag
NEE-V524e-structure
NEE-V524e-sds
NEE-V524c Influenza Influenza A [A/Victoria/4897/2022(H1N1)] Neuraminidase (NA) Protein, His Tag
NEE-V524c-structure
NEE-V524c-sds
NEE-V524a Influenza Influenza A [Sydney/5/2021(H1N1)] Neuraminidase (NA) Protein, His Tag
NEE-V524a-structure
NEE-V524a-sds
NEE-V5249 Influenza Influenza A [turkey/Germany-MV/R2472/2014(H5N8)] Neuraminidase (NA) Protein, His Tag
NEE-V5249-structure
NEE-V5249-sds
NE2-V5249 Influenza Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (MALS verified)
NE2-V5249-structure
NE2-V5249-sds
NEE-V5247 Influenza Influenza A [Darwin/6/2021] Neuraminidase (NA) Protein, His Tag (SPR verified)
NEE-V5247-structure
NEE-V5247-sds
NEE-V5248 Influenza Influenza A [Sydney/5/2021] Neuraminidase (NA) Protein, His Tag (SPR verified)
NEE-V5248-structure
NEE-V5248-sds
NEE-V5246 Influenza Influenza B [PHUKET/3073/2013] Neuraminidase (NA) Protein, His Tag (SPR verified)
NEE-V5246-structure
NEE-V5246-sds
NEE-V5245 Influenza Influenza B [Austria/1359417/2021] Neuraminidase (NA) Protein, His Tag (MALS & SPR verified)
NEE-V5245-structure
NEE-V5245-sds
NEE-V5244 Influenza Influenza A [Wisconsin/67/2022] Neuraminidase (NA) Protein, His Tag
NEE-V5244-structure
NEE-V55H5 Influenza Influenza A [A/Victoria/4897/2022 (H1N1)] Neuraminidase (NA) Protein, His Tag
NEE-V55H5-structure
ACRO Quality

Part of Bioactivity data

NEE-V524m-SPR
Neuraminidase (NA) SPR

a-Neu5Ac-PAA-biotin immobilized on SA Chip can bind Influenza A [Wisconsin/67/2022(H1N1)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524m) with an affinity constant of 7.40 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
NEE-V524h-SPR
Neuraminidase (NA) SPR

a-Neu5Ac-PAA-biotin immobilized on SA Chip can bind Influenza A [Guangdong/18SF020(H5N6)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524h) with an affinity constant of 42.7 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

NA,Neuraminidase

Background

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Laninamivir Octanoate Hydrate CS-8958; R-118958 Approved Daiichi Sankyo Co Ltd Inavir Japan Influenza B virus infection; Influenza A virus infections Daiichi Sankyo Co Ltd 2010-09-10 Influenza A virus infections; Influenza, Human; Asthma; Influenza B virus infection Details
Peramivir Hydrate JNJ-2; BCX-1812; S-021812; RWJ-270201 Approved Biocryst Pharmaceuticals Inc 力纬, Alpivab, Rapivab, Rapiacta, Peramiflu Japan Influenza, Human Biocryst Pharmaceuticals Inc 2010-01-13 Cough; Headache; Myalgia; Influenza A virus infections; Fatigue; Musculoskeletal Pain; Influenza, Human; Fever; Nasal Obstruction; Arthralgia; Influenza B virus infection; Pharyngitis Details
Zanamivir GG-167; GR-121167; GR-121167X; 4-Guanidino-Neu5Ac2en Approved Glaxosmithkline Plc 依乐韦, Relenza United States Influenza, Human Glaxosmithkline Plc 1999-07-26 Orthomyxoviridae Infections; Diabetes Mellitus, Type 2; Influenza, Human; Arthralgia; Dengue Details
Oseltamivir Phosphate Ro-64-0796; GS-4104; RO-640796; GS-4104-002; EN-241104; RO-640796/002; GS-4104/002 Approved F. Hoffmann-La Roche Ltd Tamiflu, Hanmi Flu, 达菲 Switzerland Influenza, Human F. Hoffmann-La Roche Ltd 1999-09-21 Purpura, Thrombocytopenic, Idiopathic; Influenza A virus infections; Influenza, Human; Influenza in Birds; Obesity; Kidney Failure, Chronic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Oseltamivir/Pimodivir Phase 1 Clinical Johnson & Johnson Influenza A virus infections Details
AV-5080 AV-5080 Phase 3 Clinical Viriom Inc Influenza, Human Details
HNC042 HNC-042 Phase 1 Clinical Guangzhou Henovcom Bioscience Co Ltd Influenza A virus infections; Influenza, Human; Influenza B virus infection Details
Oseltamivir orally disintegrating tablets HY-100209 Phase 1 Clinical Hefei Industrial Pharmaceutical Co Ltd Influenza A virus infections; Influenza B virus infection Details

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