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Brief Information

Name:Microtubule-associated protein tau
Target Synonym:MAPT,MTBT1,Paired helical filament-tau,MAPTL,Microtubule Associated Protein Tau,G Protein Beta1/Gamma2 Subunit-Interacting Factor 1,Protein Phosphatase 1, Regulatory Subunit 103,Neurofibrillary Tangle Protein,PHF-Tau,TAU,Microtubule-Associated Protein Tau, Isoform 4,Microtubule-Associated Protein Tau,PPP1R103,FTDP-17,MTBT2,DDPAC,MSTD,PPND,tau Proteins,MGC138549,FLJ31424
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:34
Lastest Research Phase:Approved

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Part of Bioactivity data

CHEK-ATP087-Cell-based assay

FACS analysis of Tau-K18 (GFP) on HEK293/Human Tau-K18 (GFP) Stable Cell Line.
HEK293/Human Tau-K18 (GFP) Stable Cell Line was red line, negative control HEK293 cells was grey line (QC tested).


Immobilized Human Tau-441 GSK-3beta-phosphorylated protein, His Tag (Cat. No. TAU-H5147) at 1 μg/mL (100 μL/well) can bind Anti-Phospho-Tau (Thr181) Monoclonal Antibody, Mouse IgG with a linear range of 1-31 ng/mL (QC tested).

Tau MALS images

The purity of Human Tau-441 (K18, P301L) Protein, Tag Free (Cat. No. TAU-H5118) is more than 85% and the molecular weight of this protein is around 12-18 kDa verified by SEC-MALS.

Synonym Name



Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Flortaucipir F18 18F-AV-1451; T807; F-18-AV-1451 Approved Siemens Medical Solution Tauvid United States Alzheimer Disease Avid Radiopharmaceuticals Inc 2020-05-28 Alzheimer Disease; Frontotemporal Dementia; Neurodegenerative Diseases; Cognition Disorders; Corticobasal degeneration; Cognitive Dysfunction; Dementia; Tauopathies; Parkinson Disease; Supranuclear Palsy, Progressive; Pick Disease of the Brain; Chronic Traumatic Encephalopathy; Aphasia, Primary Progressive; Brain Concussion; Brain Injuries, Traumatic; Depression; Brain Injuries Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Buntanetap ANVS-405; ANVS-401 Phase 3 Clinical Raptor Pharmaceutical Down Syndrome; Chronic Traumatic Encephalopathy; Parkinson Disease; Alzheimer Disease; Cognitive Dysfunction; Frontotemporal Dementia Details
Florzolotau (Aprinoia Therapeutics) [18F]APN-1607; [18F]MNI-958; APN-0000455; F0-PBB3; PM-PBB3; [18F]PM-PBB3; APN-1607; 18F-PM-PBB3; 18F-APN-1607 Phase 3 Clinical Aprinoia Therapeutics Ltd Supranuclear Palsy, Progressive; Nerve Degeneration; Alzheimer Disease; Cognitive Dysfunction; Diagnostic agents; Cognition Disorders Details
E-2814 E-2814 Phase 3 Clinical Eisai Co Ltd Dementia; Alzheimer Disease Details
Izaflortaucipir F-18 [18F]PI-2620; PI-2620; 18F-PI-2620 Phase 3 Clinical Piramal, Ac Immune Sa Hypotension; Supranuclear Palsy, Progressive; Brain Concussion; Opioid-Related Disorders; Frontotemporal Lobar Degeneration; Alzheimer Disease; Cognitive Dysfunction Details
Leuco methylthioninium LMT-X; TRX-0237; Leuco-MTx; LMTM; L-MTx; HMTM Phase 3 Clinical Taurx Pharmaceuticals Alzheimer Disease; Cognitive Dysfunction; Frontotemporal Dementia Details
Zagotenemab LY-3303560 Phase 2 Clinical Eli Lilly And Company Alzheimer Disease Details
Posdinemab JNJ-63733657; JNJ-3657 Phase 2 Clinical Johnson & Johnson Innovative Medicine Alzheimer Disease; Cognitive Dysfunction; Dementia Details
[18F]GTP-1 [18F]GTP-1 Phase 2 Clinical Genentech Inc Alzheimer Disease Details
FluoroTau [18F]THK-5351; GE-216; F-18-THK-5351 Phase 2 Clinical Tohoku University Kidney Neoplasms; Carcinoma, Renal Cell; Alzheimer Disease; Cognitive Dysfunction; Neurodegenerative Diseases; Diabetes Mellitus Details
[18F]THK-5105 [18F]THK-5105 Phase 2 Clinical Tohoku University Alzheimer Disease Details
ISIS-814907 BIIB-080; ISIS-814907; IONIS-MAPTRx; ISIS-BIIB4Rx; IONIS-BIIB4RX Phase 2 Clinical Biogen Inc, Ionis Pharmaceuticals Inc Cognitive Dysfunction; Dementia; Alzheimer Disease Details
Tilavonemab C2N-8E12; ABBV-8E12 Phase 2 Clinical C2n Diagnostics Llc Supranuclear Palsy, Progressive; Alzheimer Disease Details
Alzheimer's disease vaccine (Axon Neuroscience) AADvac-1 Phase 2 Clinical Axon Biochemicals Alzheimer Disease; Primary Progressive Nonfluent Aphasia Details
Semorinemab MTAU-9937A; MTAU9937A; RG-6100; RO7105705; RO-7105705 Phase 2 Clinical Ac Immune Sa Alzheimer Disease Details
APN-1701 [18F]AM-PBB3; 18F-AM-PBB3; APN-1701 Phase 2 Clinical National Institute Of Radiological Sciences, Aprinoia Therapeutics Ltd Nerve Degeneration; Alzheimer Disease Details
Anti-tau antibody (Prothena) PRX-005; BMS-986446 Phase 2 Clinical Prothena Alzheimer Disease; Frontotemporal Dementia Details
Bepranemab UCB-0107 Phase 2 Clinical Ucb Supranuclear Palsy, Progressive; Alzheimer Disease Details
[18F]THK-5117 [18F]THK-5117 Phase 2 Clinical Tohoku University Alzheimer Disease Details
ASN-120290 ASN-561; ASN-90; ASN-120290 Phase 1 Clinical Merck Serono Alzheimer Disease; Parkinson Disease Details
PNT-001 PNT-001 Phase 1 Clinical Pinteon Therapeutics Inc Brain Injuries, Traumatic; Alzheimer Disease Details
ReS19-T ReS19-T Phase 1 Clinical Remynd Alzheimer Disease Details
Mecripyrine Hydrochloride SCR-1693; Y-1A; Y-1 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd, NeuroDawn Pharmaceutical Co Ltd Brain Neoplasms; Alzheimer Disease Details
Lu-AF87908 Lu-AF87908; Lu-AF-87908 Phase 1 Clinical H. Lundbeck A/S Alzheimer Disease Details
RDC-5 RDC-5 Phase 1 Clinical Chronos Therapeutics Ltd Amyotrophic Lateral Sclerosis Details
MC-1 (Lilly) MC-1 (Lilly) Phase 1 Clinical Eli Lilly And Company Alzheimer Disease Details
OLX-07010 OLX07010 Phase 1 Clinical Oligomerix Inc Supranuclear Palsy, Progressive; Alzheimer Disease; Dementia; Neurodegenerative Diseases Details
Protollin Phase 1 Clinical Brigham and Women's Hospital Inc Alzheimer Disease Details
ADEL-Y01 ADEL-Y01 Phase 1 Clinical Oscotec Inc, ADEL Inc Tauopathies; Alzheimer Disease Details
MK-2214 MK-2214 Phase 1 Clinical Merck Sharp & Dohme LLC Alzheimer Disease Details
APNmAb-005 APNmAb-005 Phase 1 Clinical Aprinoia Therapeutics Ltd Nerve Degeneration; Alzheimer Disease; Tauopathies Details
XTR-006 XTR-006 Phase 1 Clinical Beijing Xiantong International Technology Co Ltd Tauopathies; Alzheimer Disease Details
NIO-752 NIO-752 Phase 1 Clinical Novartis Pharma Ag Supranuclear Palsy, Progressive; Cognitive Dysfunction; Alzheimer Disease; Neurodegenerative Diseases Details
BEY-2153 BEY-2153 Phase 1 Clinical Beyondbio Inc Alzheimer Disease Details
BIIB-076 NI-105; BIIB-076 Phase 1 Clinical Biogen Inc, Neurimmune Ag Alzheimer Disease Details
11C-PBB3 11C-PBB3 Clinical National Institute Of Radiological Sciences Alzheimer Disease Details

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