>Aneuro | Neural Factors
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. At present, more and more neural factors have been found to play a neuroprotective role in stroke, brain injury and other diseases. Once peripheral nerves are injured, protecting neurons from apoptosis is a prerequisite for nerve regeneration. Exogenous neural factors can promote survival of different types of neurons. Recent studies have shown that the combined effect of multiple factors in repairing peripheral nerve injury is better than that of a single factor, because nerve injury can cause changes in the levels of multiple peripheral neurotrophic factors and their receptors, and participate in nerve repair together. Therefore, the combined action of nerve factors is more inclined to the actual state in the body and can improve the protective effect of neurons.
Neurotrophic factors (NTFs) are a class of typical neural factors, mainly including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophic factor-3 (NT-3), neurotrophin-4 (NT-4, NT-5), neurotrophin-6 (NT-6), ciliary neurotrophic factor (CNTF), glia cell line-derived neurotrophic factor (GDNF), etc.
NGF is a type of protein that can accelerate the growth, development, differentiation and rapid maturation of central and peripheral neurons. As the earliest discovered and most thoroughly studied neurotrophic factor, it plays an important role in regulating the development, differentiation, growth, regeneration and expression of functional properties of central and peripheral neurons. NGF contains three subunits, α, β, and γ, and the active region is the β subunit.
NT-3 can maintain the survival of neural stem cells, promote their proliferation and differentiation, and maintain the survival of sensory neurons and sympathetic neurons in the peripheral nervous system and motor neurons in the central nervous system.
NT-4 is the fourth member of the neuron factor family, which plays an important role in promoting the growth, development, differentiation and maturation of neurons. It can maintain the survival of neurons, and promote repair and regeneration after neuron damage, mediate neuro-immunity-endocrine, regulate synaptic plasticity, promote the formation of neuromuscular junctions and induce collateral sprouting in normal motor neurons.
GDNF is a neural factor with unique neurotrophic properties. It can promote the survival of different neuronal subsets in the development of central and peripheral nervous systems at different stages and support the survival of midbrain dopaminergic neurons in vitro. Moreover, GDNF has been validated in various animal models of Parkinson's disease to improve conditions such as bradykinesia, stiffness and postural instability.
Midkine (MDK), also known as neurite outgrowth promoting factor-2, is a heparin-binding growth factor discovered in 1988, which has the functions of cell proliferation, cell migration, angiogenesis and fibrinolysis.
As the brand of ACROBiosystems that focused on neuroscience, Aneuro has developed a series of recombinant neural factors to support the culture and differentiation of nerve cells.
|Molecule||Cat. No.||Product Description|
|Artemin||ARN-H5118||Human Artemin Protein, Tag Free|
|BDNF||BDF-H5219||Human BDNF Protein, Native|
|Beta-NGF||BEF-H5214||Human Beta-NGF Protein, Tag Free|
|CNTF||CNF-H5114||Human CNTF Protein, Tag Free|
|CNTF R alpha||CNR-H5225||Human CNTF R alpha Protein, His Tag|
|GDNF||GDF-H5219||Human GDNF / ATF Protein, His Tag|
|GDF-M5245||Mouse GDNF / ATF Protein, His Tag|
|GMF-beta||GMA-H5145||Human GMF-beta Protein, His Tag (MALS verified)|
|MANF||MAF-H52H3||Human MANF Protein, His Tag (MALS verified)|
|Midkine||MIE-H5117||Human Midkine / Mdk Protein, Tag Free|
|MIE-M5246||Mouse Midkine / Mdk Protein, His Tag|
|MIE-M82Q8||Biotinylated Mouse Midkine / Mdk Protein, His,Avitag™|
|NT-3||NT3-H5115||Human NT-3 / Neurotrophin-3 Protein, Tag Free|
|NT-4||NT4-H5114||Human NT-4 / Neurotrophin-4 Protein, Tag Free, low endotoxin (MALS verified)|
|NGFR||NGR-H5254||Human NGFR / TNFRSF16 Protein, Fc Tag|
|Pleiotrophin||PLN-H5244||Human Pleiotrophin / PTN Protein, His Tag|
|TrkA||TRA-H5253||Human TrkA / NTRK1 (192-402) Protein, Mouse IgG2a Fc Tag|
|TRA-H5259||Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag|
|TrkB||NT2-H5228||Human TrkB / NTRK2 Protein, His Tag|
|NT2-H5254||Human TrkB / NTRK2 Protein, Fc Tag|
|TrkC||TRC-H5256||Human TrkC / NTRK3 Protein, Fc Tag|
 Ascano M， Bodmer D， Kuruvilla Ｒ． Endocytic trafficking of neurotrophins in neural development． Trends Cell Biol， 2012， 22:266 － 273.
 Shakhbazau A， Martinez JA， Xu QG， et al． Evidence for a systemic regulation of neurotrophin synthesis in response to peripheral nerve injury． J Neurochem， 2012， 122: 501－511.
 Liu K P, Ma W, Li C Y, et al. Neurotrophic factors combined with stem cells in the treatment of sciatic nerveinjury in rats: a metaanalysis. Biosci Rep, 2022, 42(1): BSR20211399
 Jafari M, Delaviz H, Torabi S, et al. The effect of muscle graft with nerve growth factor and laminin on sciatic nerve repair in rats. Basic ClinNeurosci. 2019, 10(4):333-344
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