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Aneuro | Neural Factors

Aneuro Neural Factors

Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. At present, more and more neural factors have been found to play a neuroprotective role in stroke, brain injury and other diseases. Once peripheral nerves are injured, protecting neurons from apoptosis is a prerequisite for nerve regeneration. Exogenous neural factors can promote survival of different types of neurons. Recent studies have shown that the combined effect of multiple factors in repairing peripheral nerve injury is better than that of a single factor, because nerve injury can cause changes in the levels of multiple peripheral neurotrophic factors and their receptors, and participate in nerve repair together. Therefore, the combined action of nerve factors is more inclined to the actual state in the body and can improve the protective effect of neurons.

Typical neural factors and functions

Neurotrophic factors (NTFs) are a class of typical neural factors, mainly including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophic factor-3 (NT-3), neurotrophin-4 (NT-4, NT-5), neurotrophin-6 (NT-6), ciliary neurotrophic factor (CNTF), glia cell line-derived neurotrophic factor (GDNF), etc.

NGF is a type of protein that can accelerate the growth, development, differentiation and rapid maturation of central and peripheral neurons. As the earliest discovered and most thoroughly studied neurotrophic factor, it plays an important role in regulating the development, differentiation, growth, regeneration and expression of functional properties of central and peripheral neurons. NGF contains three subunits, α, β, and γ, and the active region is the β subunit.

NT-3 can maintain the survival of neural stem cells, promote their proliferation and differentiation, and maintain the survival of sensory neurons and sympathetic neurons in the peripheral nervous system and motor neurons in the central nervous system.

NT-4 is the fourth member of the neuron factor family, which plays an important role in promoting the growth, development, differentiation and maturation of neurons. It can maintain the survival of neurons, and promote repair and regeneration after neuron damage, mediate neuro-immunity-endocrine, regulate synaptic plasticity, promote the formation of neuromuscular junctions and induce collateral sprouting in normal motor neurons.

GDNF is a neural factor with unique neurotrophic properties. It can promote the survival of different neuronal subsets in the development of central and peripheral nervous systems at different stages and support the survival of midbrain dopaminergic neurons in vitro. Moreover, GDNF has been validated in various animal models of Parkinson's disease to improve conditions such as bradykinesia, stiffness and postural instability.

Midkine (MDK), also known as neurite outgrowth promoting factor-2, is a heparin-binding growth factor discovered in 1988, which has the functions of cell proliferation, cell migration, angiogenesis and fibrinolysis.

Product List

As the brand of ACROBiosystems  that focused on neuroscience, Aneuro has developed a series of recombinant neural factors to support the culture and differentiation of nerve cells.

MoleculeCat. No.Product Description
BDNFBDF-H5219Human BDNF Protein, Native
Beta-NGFBEF-H5214Human Beta-NGF Protein, Tag Free
CNTFCNF-H5114Human CNTF Protein, Tag Free
CNTF R alphaCNR-H5225Human CNTF R alpha Protein, His Tag
GDNFGDF-H5219Human GDNF / ATF / hGDNF Protein, premium grade
GDF-M5245Mouse GDNF / ATF Protein, His Tag
GMF-betaGMA-H5145Human GMF-beta Protein, His Tag (MALS verified)
MANFMAF-H52H3Human MANF Protein, His Tag (MALS verified)
MidkineMIE-H5117Human Midkine / Mdk Protein, Tag Free
MIE-M82Q8Biotinylated Mouse Midkine / Mdk Protein, His,Avitag™
NT-4NT4-H5114Human NT-4 / Neurotrophin-4 Protein, Tag Free, low endotoxin (MALS verified)
NGFRNGR-H5254Human NGFR / TNFRSF16 Protein, Fc Tag
PleiotrophinPLN-H5244Human Pleiotrophin / PTN Protein, His Tag
TrkATRA-H5253Human TrkA / NTRK1 (192-402) Protein, Mouse IgG2a Fc Tag
TRA-H5259Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag
TrkBNT2-H5228Human TrkB / NTRK2 Protein, His Tag
NT2-H5254Human TrkB / NTRK2 Protein, Fc Tag
TrkCTRC-H5256Human TrkC / NTRK3 Protein, Fc Tag
If you have any needs or more development suggestions, please contact us .
  • [1] Ascano M, Bodmer D, Kuruvilla R. Endocytic trafficking of neurotrophins in neural development. Trends Cell Biol, 2012, 22:266 - 273.

  • [2] Shakhbazau A, Martinez JA, Xu QG, et al. Evidence for a systemic regulation of neurotrophin synthesis in response to peripheral nerve injury. J Neurochem, 2012, 122: 501-511.

  • [3] Liu K P, Ma W, Li C Y, et al. Neurotrophic factors combined with stem cells in the treatment of sciatic nerveinjury in rats: a metaanalysis. Biosci Rep, 2022, 42(1): BSR20211399

  • [4] Jafari M, Delaviz H, Torabi S, et al. The effect of muscle graft with nerve growth factor and laminin on sciatic nerve repair in rats. Basic ClinNeurosci. 2019, 10(4):333-344

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