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Apolipoprotein E

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Cat. No. Species Product Description Structure Purity Feature
APE-H5246 Human Human Apolipoprotein E / APOE Protein, His Tag
APE-H5246-structure
APE-H5246-sds

Apolipoprotein E Part of Bioactivity data

APE-H5246-ELISA
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human TREM2, His,Avitag (Cat. No. TR2-H82E7) on SA Biosensor, can bind Human Apolipoprotein E, His Tag (Cat. No. APE-H5246) with an affinity constant of 37.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Apolipoprotein E Molecule Synonym Name

Apolipoprotein E,APOE,Apo-E

Apolipoprotein E Molecule Background

APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.

Apolipoprotein E References

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