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Your Position: Home > Apolipoprotein E

Apolipoprotein E

Brief Information

Name:Apolipoprotein E
Target Synonym:APOE,Apolipoprotein E,Alzheimer Disease 2 (APOE*E4-Associated, Late Onset),Apolipoprotein E3,LDLCQ5,ApoE4,Apo-E,LPG,AD2,Apolipoproteins E
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
APE-H5256 Human Human Apolipoprotein E / APOE Protein (R154S,R176C), His Tag
APE-H5246 Human Human Apolipoprotein E / APOE Protein, His Tag

Part of Bioactivity data


Loaded Human TREM2, Fc Tag (Cat. No. TR2-H5254) on Protein A Biosensor, can bind Human Apolipoprotein E (R154S,R176C), His Tag (Cat. No. APE-H5256) with an affinity constant of 17.2 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).


Loaded Biotinylated Human TREM2, His,Avitag (Cat. No. TR2-H82E7) on SA Biosensor, can bind Human Apolipoprotein E (R154S,R176C), His Tag (Cat. No. APE-H5256) with an affinity constant of 2.08 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

Apolipoprotein E,APOE,Apo-E


APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AEM-28 AEM-28 Phase 2 Clinical Lipimetix Hypercholesterolemia; Hyperlipoproteinemia Type II Details
CN-105 CN-105 Phase 1 Clinical Cerenova Cerebral Hemorrhage; Stroke Details
LX-1001 LX-1001 Phase 1 Clinical LEXEO Therapeutics Alzheimer Disease Details

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