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GPCRs

Introduction

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins. The primary function of GPCRs is to transduce a wide and diverse array of extracellular stimuli such as biogenic amines, peptides, hormones, neurotransmitters, ions, odorants, and photons into intracellular signals that regulate a myriad of physiological processes including cell metabolism, cell differentiation, growth, neurotransmission, and sensory perception. GPCRs have also been implicated in a large number of diseases, such as type 2 diabetes mellitus (T2DM), obesity, depression, cancer, Alzheimer’s disease, and many others. Therefore, GPCRs have become the most successful drug target class in drug target for the treatment of a variety of diseases.

Structure of GPCRs

The common molecular structure of GPCRs consists of seven transmembrane alpha helices, and these domains divide the receptor into extracellular N-terminus, intracellular C-terminus, three extracellular loops and three intracellular loops.

The extracellular ring contains two highly conserved cysteine residues, which can stabilize the spatial structure of the receptor by forming disulfide bonds. There is a G-protein binding site on the intracellular loop.


Schematic diagram of the classic GPCRs

ACROBiosystems assists in the development of targeted GPCRs antibodies

It is extremely difficult to obtain biologically active soluble GPCRs antigen because of the limited extracellular exposure of GPCRs target, low cell surface expression, protein aggregation and other factors. The full-length structure to ensure the natural conformation of GPCRs antigen is of great significance to drug development. ACROBiosystems has specially built platform solutions of VLP, Micelle Detergent and Nanodisc to provide you with full-length GPCRs proteins including GPRC5D, CCR5, CCR8, which can be used for Immunization, ELISA, SPR, BLI etc.

Product List
PlatformMoleculeCat. No.Production    Discription
VLP PlatformGPRC5DGPD-H52P5Human GPRC5D Full Length Protein-VLP (HEK293)
CCR5CC5-H52P3Human CCR5 Full Length Protein-VLP (HEK293)
CCR8CC8-H52P4Human CCR8 Full Length Protein-VLP (HEK293)
VLPVLP-H52C5Virus-Like Particle (VLP) isotype control
Micelle Detergent PlatformGPRC5DGPD-H52D3Human GPRC5D Protein, Flag,His Tag
CCR5CC5-H52D1Human CCR5 Protein, Flag,His Tag
BufferDC-11200 x DDM CHS buffer
Nanodisc PlatformGPRC5DGPD-H52D4Human GPRC5D Protein, Flag,His Tag (Nanodisc)
GPRC5DGPD-H82D4Biotinylated Human GPRC5D Protein, His,Avitag™&Flag Tag (Nanodisc)
MSP1D1APO-H51H3Human MSP1D1 Protein, His Tag (Nanodisc)
MSP1D1APO-H81Q5Biotinylated Human MSP1D1 Protein, His,Avitag™ (Nanodisc)

More GPCRs related information

>>> GPCRs: From signal pathways to targeted drug development

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