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Your Position: Home > CCR5


Brief Information

Name:C-C chemokine receptor type 5
Target Synonym:CCR-5,Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene),C-C Motif Chemokine Receptor 5 A159A,Chemokine Recptor CCR5 Delta32,C-C Chemokine Receptor Type 5,Chemokine Receptor CCR5,CD195 Antigen,C-C CKR-5,CCCKR5,IDDM22,CKR-5,CKR5,Receptors, CCR5,C-C Motif Chemokine Receptor 5,CD195,CHEMR13,CCR5,HIV-1 fusion coreceptor,C-C Motif Chemokine Receptor 5 (Gene/Pseudogene),Chemokine (C-C Motif) Receptor 5,CC-CKR-5,CMKBR5
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CC5-H52P3 Human Human CCR5 Full Length Protein-VLP (HEK293)
CC5-H52D1 Human Human CCR5 Protein, Flag,His Tag

Part of Bioactivity data


Human CCR5, Flag,His Tag (Cat. No. CC5-H52D1) captured on CM5 chip via anti-His antibody can bind Anti-CCR5 antibody (Human IgG1) with an affinity constant of 0.0737 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore T200) (Routinely tested).


Purified NA/LE Mouse Anti-Human CD195 (Clone: 2D7) (Mouse IgG2a) captured on CM5 chip via anti-mouse antibodies surface can bind Human CCR5, Flag,His Tag (Cat. No. CC5-H52D1) with an affinity constant of 7.51 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore T200) (Routinely tested).

Synonym Name



Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.5 Publications (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Maraviroc MVC; UK-427857 Approved Viiv Healthcare Celsentri, Selzentry Mainland China HIV Infections Godecke Gmbh 2007-08-06 HIV Infections Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BMS-687681 BMS-687681 Phase 1 Clinical Neoplasms Details
Cenicriviroc mesylate/Tropifexor LJC-242 Phase 2 Clinical Novartis Pharma Ag Non-alcoholic Fatty Liver Disease Details
Thioraviroc Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences HIV Infections Details
OB-002H OB-002; 5P12-RANTES Details
Anti-CCR5 monoclonal antibody (Human Genome Sciences) HGS-1025 Glaxosmithkline Plc Details
SB-728-HSC SB-728-HSC; SB-728-HSPC; SB-728mR-HSPC Sangamo Biosciences Details
PF-04634817 PF-4634817; PF-04634817; PF-46334817 Pfizer Pharmaceuticals Ltd (China) Details
Aplaviroc hydrochloride AK-602; ONO-4128; GW-873140 Ono Pharmaceutical Co Ltd Details
GSK-706769 GSK-706769 Glaxosmithkline Plc Details
BMS-813160 BMS-813160 Bristol-Myers Squibb Company Details
Leronlimab PRO-140; PA-14; HuPRO-140 Cytodyn Inc Details
Vicriviroc SCH-D; MK-4176; SCH-417; Sch-417690 Merck & Co Inc Details
INCB-009471 INCB-9471; INCB-009471 Incyte Corp Details
CAL-1-transduced hematopoietic stem cell gene therapy (Calimmune) Cal-1 Calimmune Details
AZD-5672 AZD5672; AZD-5672 Astrazeneca Plc Details
PF-232798 PF-232798; PF-00232798 Pfizer Inc, Viiv Healthcare Details
AGT 103-T AGT 103-T American Gene Technologies International Inc Details
SB-728-T SB-728mR-T; SB-728-T Sangamo Biosciences Details
Emtricitabine/Maraviroc/Tenofovir Disoproxil Fumarate University Of Texas Medical Branch, Oak Crest Institute Of Science, Eunice Kennedy Shriver National Institute Of Child Health And Human Development, Auritec Pharmaceuticals Details
Lamivudine/Maraviroc/Zidovudine GSK-2838510 Glaxosmithkline Plc Details
Dapivirine/Maraviroc Microbicide Trials Network, International Partnership For Microbicides Details

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