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Alpha-Synuclein

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Cat. No. Species Product Description Structure Purity Feature
ALN-H52H8 Human Human Alpha-Synuclein Protein, His Tag
ALN-H52H8-structure
ALN-H52H8-sds

Alpha-Synuclein Molecule Synonym Name

SNCA,NACP,PARK1,alpha-Synuclein

Alpha-Synuclein Molecule Background

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Alpha-Synuclein References

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