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Fc Receptor Proteins

INTRODUCTION

The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half life, while that between the Fc fragment and FCGRIIIA (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Hence, screening for desired binding affinity to these Fc receptors is an essential component in the development of a therapeutic mAb (monoclonal antibody).

ACROBiosystems offers a comprehensive collection of recombinant Fc receptor proteins, including their common variants, to help expedite your mAb development.


PRODUCT LIST
Molecule Catalog No. Species Product Name Structure Purity Features
FcRn / FCGRT
& B2M
FCM-H5286
FcRn / FCGRT & B2M Heterodimer Protein FCM-H5286-STC1.jpg

FCM-H8286
Biotinylated FcRn / FCGRT & B2M, ultra sensitivity (primary amine labeling) FCM-H8286-STC1.jpg

FCM-H82W4
Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) FCM-H82W4-STC1.jpg

FCM-M52W2
FcRn / FCGRT & B2M Heterodimer Protein FCM-M52W2-STC1.jpg

FCM-M82W6
Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) FCM-M82W6-STC1.jpg

FCM-R5287
FcRn / FCGRT & B2M Heterodimer Protein FCM-R5287-STC1.jpg

FCM-R82W7
Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) FCM-R82W7-STC1.jpg

FCM-C5284
FcRn / FCGRT & B2M Heterodimer Protein FCM-C5284-STC1.jpg

FCM-C82W5
Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) FCM-C82W5-STC1.jpg

FCM-P5280
FcRn / FCGRT & B2M Heterodimer Protein FCM-P5280-STC1.jpg
FCN-F82W3
Biotinylated Feline FcRn / FCGRT & B2M Heterodimer Protein, His Tag & Avi Tag (Avitag™) FCN-F82W3-STC1.jpg
Fc gamma RIIIA / CD16a CD8-H52H4
FCGR3A / CD16a (V176) Protein CD8-H52H4-STC1.jpg

CDA-H5220
FCGR3A / CD16a (F176) Protein CDA-H5220-STC1.jpg

CDA-H82E8
Biotinylated Fc gamma RIIIA / CD16a (F176), Avi Tag (Avitag™) CDA-H82E8-STC1.jpg

CDA-H82E9
Biotinylated Fc gamma RIIIA / CD16a (V176), Avi Tag (Avitag™) CDA-H82E9-STC1.jpg

CDA-M52H8
FCGR3A / CD16a Protein CDA-M52H8-STC1.jpg

Fc gamma RIIIB / CD16b CDB-H5222
Human Fc gamma RIIIB / CD16b (NA2) Protein CDB-H5222-STC1.jpg
CDB-H82E4
Biotinylated Human Fc gamma RIIIB / CD16b (NA1), His Tag & Avi Tag (Avitag™) CDB-H82E4-STC1.jpg
CDB-H5227
Human Fc gamma RIIIB / CD16b (NA1) Protein, His tag CDB-H5227-STC1.jpg
Fc gamma RIIA / CD32a CD1-H5223
FcGR2A / CD32a (H167) Protein CD1-H5223-STC1.jpg

CDA-H5221
Fc gamma RIIA / CD32a (R167) Protein CDA-H5221-STC1.jpg

CDA-H82E6
Biotinylated Fc gamma RIIA / CD32a (H167), Avi Tag (Avitag™) CDA-H82E6-STC1.jpg

CDA-H82E7
Biotinylated Fc gamma RIIA / CD32a (R167), Avi Tag (Avitag™) CDA-H82E7-STC1.jpg

Fc gamma RIIB / CD32b CDB-H5228
Fc gamma RIIB / CD32b Protein CDB-H5228-STC1.jpg

Fc gamma RI / CD64 FCA-H52H2
Fc gamma RI / CD64 Protein FCA-H52H2-STC1.jpg

CD4-M5227
Fc gamma RI / CD64 Protein CD4-M5227-STC1.jpg

FCA-H82E8
Biotinylated Human Fc gamma RI / CD64, His Tag, Avi Tag (Avitag™) FCA-H82E8-STC1.jpg

CD23 CD3-H82Q5
Biotinylated Human CD23 / Fc epsilon RII Protein, His Tag & Avi Tag (Avitag™) CD3-H82Q5-STC1.jpg

Fc gamma RIII / CD16 FC6-C82E0
Biotinylated Cynomolgus FCGR3 / CD16 Protein, His Tag & Avi Tag (Avitag™) FC6-C52H9-STC1.jpg

FC6-C52H9
Cynomolgus FCGR3 / CD16 Protein, His Tag FC6-C52H9-STC1.jpg

KEY FEATURES

Authentic Human Cell-Expressed Proteins

ACROBiosystems Fc receptor proteins are exclusively produced in HEK293 cells. The proteins retain their authentic post-translational processing, which often translates into high bioactivity and stability.

High Quality and Binding Activity

The consistency in purity and bioactivity is essential in the successful production of biotinylated proteins. All our proteins are evaluated by a variety of methods throughout the production process to ensure all relevant requirements are met.

  • Purity greater than 95% by SDS-PAGE and SEC-HPLC

  • Bioactivity validated in functional ELISA and SPR

  • Endotoxin less than 1EU/µg by the LAL method.

Fig. 1 The purity of human FcRn (Cat. No. FCM-H5286) was greater than 95% as determined in a HPLC analysis.

Fig. 2 Immobilized Human FcRn / FCGRT & B2M Heterodimer Protein (Cat. No. FCM-H5286) on CM5 Chip, can bind Herceptin with an affinity constant of 0.427 μM as determined in SPR assay (Biacore 8K)  (Routinely tested).

Biotinylated Proteins Available

The use of biotin labeling can make your assay development much easier. We offer a variety of ready-to-use biotinylated Fc receptors. These proteins are produced using our in-house developed labeling techniques, which confers high bioactivity and minimal batch-to-batch variation.

Fig. 3 Immobilized Biotinylated Human FcRn / FCGRT & B2M Heterodimer Protein (Cat.No. FCM-H82W4) on SA chip, can bind Herceptin with an affinity constant of 1.47 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

LATEST CITATIONS

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