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Your Position: Home > CCR8

CCR8

Brief Information

Name:C-C chemokine receptor type 8
Target Synonym:Chemokine (C-C) Receptor 8,CC Chemokine Receptor 8,CDw198 Antigen,C-C CKR-8,CC-CKR-8,CCR-8,CMKBRL2,C-C Motif Chemokine Receptor 8,CC chemokine receptor CHEMR1,C-C chemokine receptor type 8,Chemokine (C-C Motif) Receptor 8,C-C Chemokine Receptor Type 8,CC Chemokine Receptor CHEMR1,Chemokine Receptor-Like 1,Chemokine (C-C) Receptor-Like 2,CC-Chemokine Receptor Chemr1,CD_antigen=CDw198,Chemokine receptor-like 1,CKRL1,CKR-L1,CMKBR8,GPRCY6,GPR-CY6,TER1,CDw198,CY6
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

Licensing

Project item Indications Research phase Cooperation demands
BSW202202 Solid tumor Preclinical sequence authorization or project transfer

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Cat. No. Species Product Description Structure Purity Feature
CHEK-ATP140 Human HEK293/Human CCR8 Stable Cell Line
CC8-H52P4 Human Human CCR8 Full Length Protein (VLP)
ACRO Quality

Part of Bioactivity data

CC8-H52P4-SPR
CCR8 ELISA

Immobilized Human CCR8 Full Length Protein-VLP (Cat. No. CC8-H52P4) at 10 μg/mL (100 μL/well) can bind Anti-CCR8 Antibody, Human IgG1 with a linear range of 0.078-2.5 μg/mL (QC tested).

Protocol

Synonym Name

CC chemokine receptor 8,CD198,,ChemR1,CKRL1,CKR-L1,CKRL1,CY6,GPRCL1,GPRCY6,GPR-CY6,TER-1

Background

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BAY-3375968 BAY-3375968 Phase 1 Clinical Bayer AG Solid tumours; Neoplasms Details
IPG-7236 IPG-7236; IPG-007 Phase 1 Clinical Nanjing Immunophage Biotech Co Ltd Solid tumours; Dermatitis, Atopic Details
JTX-1811 JTX-1811; GS-1811 Phase 1 Clinical Jounce Therapeutics Inc Solid tumours Details
S-531011 S-531011 Phase 2 Clinical Shionogi Inc Solid tumours Details
LM-108 LM-108 Phase 2 Clinical LaNova Medicines Ltd Solid tumours Details
SRF-114 SRF-114 Phase 2 Clinical Surface Oncology Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms Details
HBM-1022 HBM-1022 Phase 1 Clinical Neoplasms Details
BMS-986340 BMS-986340 Phase 2 Clinical Eeig Bristol-Myers Squibb Manufacturing Company Bristol-Myers Squibb Srl Ovarian Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Neoplasms; Colorectal Neoplasms; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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