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Your Position: Home > CXCR4


Brief Information

Name:C-X-C motif chemokine receptor 4
Target Synonym:NPYRL,CD184,CXCR4,CXC-R4,SDF-1 receptor,LAP-3,Fusin,FB22,HM89,Seven-Transmembrane-Segment Receptor, Spleen,Chemokine (C-X-C Motif), Receptor 4 (Fusin),Seven Transmembrane Helix Receptor,C-X-C Chemokine Receptor Type 4,Neuropeptide Y Receptor Y3,Neuropeptide Y3 Receptor,Chemokine Receptor,D2S201E,HSY3RR,NPYY3R,CXCR-4,NPY3R,WHIMS,LAP3,NPYR,WHIM,Receptors, CXCR4,LCR1,LESTR,LPS-associated protein 3,Leukocyte-Derived Seven Transmembrane Domain Receptor,Stromal Cell-Derived Factor 1 Receptor,Chemokine
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CX4-H5219 Human Human CXCR4 / CD184 Full Length Protein-VLP (HEK293)
CX4-H5269 Human Human CXCR4 / CD184 Protein, Fc Tag

Part of Bioactivity data

Human CXCR4 Full Length Protein-VLPHuman CXCR4 Full Length Protein-VLP (Cat. No. CX4-H5219) ELISA bioactivity

Immobilized Human CXCR4 Full Length Protein-VLP (Cat. No. CX4-H5219) at 5 μg/mL (100 μL/well) can bind Human ulocuplumab, Human IgG4 with a linear range of 1-31 ng/mL (QC tested).

Synonym Name



C-X-C chemokine receptor type 4 is also known as fusin or CD184 (cluster of differentiation 184), CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4 using HIV is a consequence or a cause of immunodeficiency.CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. SDF-1 and CXCR4 were believed to be a relatively "monogamous" ligand-receptor pair (other chemokines tend to use several different chemokine receptors in a fairly "promiscuous" manner). Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. Chronic exposure to THC increased T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes. Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Plerixafor SDZ-SID-791; JM-3100; JKL-169; AMD-3100; PLR-001 Approved Genzyme Corp 释倍灵, Mozobil, Mobozil Mainland China Lymphoma, Non-Hodgkin; Multiple Myeloma Genzyme Europe Bv 2008-12-15 Hematopoietic stem cell transplantation (HSCT); Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Hodgkin Disease; Kidney Diseases; Myelodysplastic Syndromes; Rejection of organ transplantation; Multiple Myeloma; Neuroblastoma; Brain Neoplasms; Sarcoma, Ewing; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ulocuplumab MDX-1338; BMS-936564 Phase 2 Clinical Bristol-Myers Squibb Company Leukemia; Solid tumours; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Multiple Myeloma; Lymphoma, Follicular; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell Details
NRP-2945 NNZ-4945; NRP-2945 Phase 2 Clinical Neuren Pharmaceuticals Epilepsy Details
Balixafortide POL-6326 Phase 3 Clinical Polyphor Ltd Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Myelodysplastic Syndromes; Myeloproliferative Disorders; Multiple Myeloma; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell Details
GMI-1359 GMI-1359 Phase 1 Clinical Glycomimetics Pharmaceutical Breast Neoplasms; Metastatic breast cancer Details
X-4136 X-4136 Clinical X4 Pharmaceuticals Lymphoma, B-Cell Details
PTX-9908 PTX-9908 Phase 2 Clinical Pertinax Therapeutics Liver Neoplasms; Carcinoma, Hepatocellular Details
LY-2510924 T-134; LY-2510924 Phase 2 Clinical Eli Lilly And Company Solid tumours; Carcinoma, Renal Cell; Small Cell Lung Carcinoma Details
AD-214 AD-214 Phase 1 Clinical Lung Diseases, Interstitial; Gastroesophageal Reflux Details
MSX-122 Q-122; WZ-40; MSX-122 Phase 2 Clinical Altiris Therapeutics Vasomotor symptom; Solid tumours; Hot Flashes Details
Motixafortide BKT-140; BL-8040; TF-14016; TN-14003; 4F-Benzoyl-TN14003 Phase 3 Clinical Biokine Hematopoietic stem cell transplantation (HSCT); Esophageal Neoplasms; Pancreatic Neoplasms; Myelodysplastic Syndromes; Multiple Myeloma; Anemia, Aplastic; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
JVS-100 SRX-100; ACRX-100; GP-51801; GP51801; JVS-100 Phase 2 Clinical Cleveland Clinic Heart Failure; Ischemia; Peripheral Arterial Disease Details
[68Ga]Pentixafor Phase 2 Clinical The University Of Iowa Central Nervous System Neoplasms; Neuroendocrine Tumors; Diagnostic agents Details
Mavorixafor AMD-11070; X4P-001-IO; AMD-070; X4P-001; X4P-001-RD; X4P-001-LD; ABSK-081 Phase 3 Clinical Genzyme Corp HIV Infections; WHIM syndrome; Neutropenia; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Waldenstrom Macroglobulinemia; Melanoma Details

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