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Brief Information

Name:Neurotrophic tyrosine kinase receptor type 2
Target Synonym:EC:,Tropomyosin-related kinase B,Trk-B,GP145-TrkB,NTRK2,Neurotrophic Tyrosine Kinase Receptor Type 2,TRKB,BDNF-Tropomyosine Receptor Kinase B,BDNF/NT-3 Growth Factors Receptor,Tyrosine Kinase Receptor B,TrkB Tyrosine Kinase,EC,OBHD,Receptor, trkB,Neurotrophic Receptor Tyrosine Kinase 2,Neurotrophic Tyrosine Kinase, Receptor, Type 2,EIEE58,EC 2.7.10
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
NT2-H5228 Human Human TrkB / NTRK2 Protein, His Tag
NT2-H5254 Human Human TrkB / NTRK2 Protein, Fc Tag

Synonym Name



Neurotrophic tyrosine kinase receptor type 2 (NTRK2) is also known as BDNF/NT-3 growth factors receptor, Tropomyosin-related kinase B (TRKB) and TrkB tyrosine kinase, which belongs to the protein kinase superfamily or Tyr protein kinase family. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is ¡°ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate¡±. NTRK2 / TrkB involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell Takeda 2012-11-29 Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Pain; Esophageal Neoplasms; Glioblastoma; Kidney Diseases; Prostatic Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Thyroid Neoplasms; Carcinoma, Neuroendocrine; Lymphoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Larotrectinib sulfate LOXO-101; ARRY-470; BAY-2757556 Approved Array Biopharma Vitrakvi Japan Solid tumours Bayer Yakuhin Ltd 2018-11-26 Solid tumours; Neoplasms Details
Entrectinib NMS-E628; RXDX-101; RG-6268 Approved Nerviano Medical Sciences Rozlytrek EU Solid tumours; Carcinoma, Non-Small-Cell Lung Roche Registration Gmbh 2019-06-18 Cholangiocarcinoma; Melanoma; Thyroid Cancer, Papillary; Carcinoma, Non-Small-Cell Lung; Lymphoma, Large-Cell, Anaplastic; Hepatic Insufficiency; Colorectal Neoplasms; Brain Neoplasms; Breast Neoplasms; Solid tumours; Sarcoma; Neuroendocrine Tumors; Central Nervous System Neoplasms; Salivary Gland Neoplasms; Pancreatic Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Head and Neck Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HG-030 HG-030 Phase 1 Clinical Hitgen Inc Solid tumours Details
Altiratinib DP-5164; DCC-2701; DCC-22701; T-678746713 Phase 1 Clinical Deciphera Solid tumours; Neoplasms Details
Lestaurtinib SP-924; CEP-701; KT-5555; SPM-924; A-154475.0 Phase 3 Clinical Kyowa Hakko Kirin Leukemia, Myeloid; Bone Marrow Neoplasms; Polycythemia Vera; Prostatic Neoplasms; Psoriasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Thrombocythemia, Essential Details
ACD-856 ACD-856 Phase 1 Clinical Alzecure Pharma Ab Alzheimer Disease; Cognition Disorders Details

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