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Browse By Molecule Name --->B7-2/CD86 Molecule

B7-2/CD86 Molecule  


B7-2 / CD86 Molecule Synonym Name

CD86,B7-2,B70,CD28LG2,LAB72,MGC34413

B7-2 / CD86 Protein Products

Cat No Species Product Description
CD6-C5254CynomolgusCynomolgus B7-2 / CD86 Protein, Fc Tag
CD6-C52H5CynomolgusCynomolgus B7-2 / CD86 Protein (HPLC-verified)
CD6-H5223HumanHuman B7-2 / CD86 Protein
CD6-H5257HumanHuman B7-2 / CD86 Protein, Fc Tag
CD6-H82E2HumanBiotinylated Human B7-2 / CD86 Protein, Avi Tag (Avitag?)
CD6-H82F5HumanBiotinylated Human B7-2 / CD86 Protein, Fc Tag, Avi Tag (Avitag?)
CD6-M5251MouseMouse B7-2 / CD86 Protein, Fc Tag
CD6-M52H0MouseMouse B7-2 / CD86 Protein

B7-2 / CD86 Molecule Background

Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.

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