BMP-2 /BMP2 Molecule
BMP-2 Molecule Synonym Name
BMP-2 Protein Products
|Cat No||Species||Product Description|
|BM2-H4117||Human||Human BMP-2 Protein, Tag Free|
BMP-2 Molecule Background
Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.
- (1) Lai, T.H. et al., (2008) Prostate. 68: 1341-1353.
- (2) Kruithof BP,et al. Genesis. 2011, Genesis, 49(11):841-50.
- (3) Grgurevic L, et al. Biochem Biophys Res Commun. 2011 Apr 29;408(1):25-31.