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Browse By Molecule Name --->CPE-Carboxypeptidase-E-Molecule

CPE-Carboxypeptidase-E-Molecule  


CPE Molecule Synonym Name

Carboxypeptidase E,CPE,carboxypeptidase,enkephalin convertase,CPH

CPE Protein Products

Cat No Species Product Description
CAE-H5225 Human Human Carboxypeptidase E / CPE Protein
CAE-M5222 Mouse Mouse Carboxypeptidase E / CPE Protein

CPE Molecule Background

Carboxypeptidase E (CPE) is also known as Carboxypeptidase H or enkephalin convertase. Carboxypeptidase E cleaves C-terminal amino acid residues and is involved in neuropeptide processing. It is a peripheral membrane protein. CPE specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Carboxypeptidase E appears to have several functions. The active form of carboxypeptidase E was shown to be in secretory vesicles, where it acts as an exopeptidase to activate neuropeptides, It does that by cleaving off basic C-terminal amino acids, producing the active form of the peptide. Products of carboxypeptidase E include insulin, enkephalin, and most other neuroendocrine peptides.It has also been proposed that membrane-associated carboxypeptidase E acts as a sorting signal for regulated secretory proteins in the trans-Golgi network of the pituitary and in secretory granules; regulated secretory proteins are mostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe, display endocrine disorders like obesity and infertility.

Reference

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