CPE Molecule Synonym Name
Carboxypeptidase E,CPE,carboxypeptidase,enkephalin convertase,CPH
CPE Protein Products
|Cat No||Species||Product Description|
|CAE-H5225||Human||Human Carboxypeptidase E / CPE Protein|
|CAE-M5222||Mouse||Mouse Carboxypeptidase E / CPE Protein|
CPE Molecule Background
Carboxypeptidase E (CPE) is also known as Carboxypeptidase H or enkephalin convertase. Carboxypeptidase E cleaves C-terminal amino acid residues and is involved in neuropeptide processing. It is a peripheral membrane protein. CPE specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Carboxypeptidase E appears to have several functions. The active form of carboxypeptidase E was shown to be in secretory vesicles, where it acts as an exopeptidase to activate neuropeptides, It does that by cleaving off basic C-terminal amino acids, producing the active form of the peptide. Products of carboxypeptidase E include insulin, enkephalin, and most other neuroendocrine peptides.It has also been proposed that membrane-associated carboxypeptidase E acts as a sorting signal for regulated secretory proteins in the trans-Golgi network of the pituitary and in secretory granules; regulated secretory proteins are mostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe, display endocrine disorders like obesity and infertility.
- (1) Manser, E. et al., 1990, Biochem. J. 267: 517-525.
- (2) Jeffrey, K.D. et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105: 8452-8457.
- (3) Dhanvantari,S. et al., 2000, J. Biol. Chem. 275: 29887-29893.