CD19 / CVID3 Molecule
CD19 Molecule Synonym Name
CD19 Protein Products
|Cat No||Species||Product Description|
|CD9-C5251||Rhesus macaque||Rhesus macaque CD19 (20-292) Protein, Fc Tag|
|CD9-H5226||Human||Human CD19 (20-291) Protein|
|CD9-H5255||Human||Human CD19 (20-278) Protein, Fc Tag|
|CD9-H5259||Human||Human CD19 (20-291) Protein, Fc Tag|
|CD9-H8259||Human||Biotinylated Human CD19, Fc Tag, ultra sensitivity (primary amine labeling)|
CD19 Molecule Background
B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I? membrane protein and contains two?Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.
- (1) Kozmik Z., et al., 1992, Mol. Cell. Biol. 12:2662-2672.
- (2) Kuroki K., et al., 2002, Genes Immun. 3:S21-S30.
- (3) Stamenkovic I., 1998, Seed B.J. Exp. Med. 168:1205-1210.