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TNF-alpha / TNFa Molecule  


TNF-alpha Molecule Synonym Name

DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα

TNF-alpha Protein Products

Cat No Species Product Description
TNA-H4211HumanActiveMax? Recombinant Human TNF-alpha (HPLC-verified)
TNA-H5228HumanHuman TNF-alpha Protein, His Tag
TNA-H8211HumanBiotinylated Human TNF-alpha, epitope tag free, ultra sensitivity (primary amine labeling)
TNA-H821RHumanBiotinylated Human TNF-alpha, epitope tag free, ultra sensitivity (primary amine labeling, long spacer)
TNA-H82E3HumanBiotinylated Human TNF-alpha (HPLC-verified), Avi Tag (Avitag?)
TNA-M82E9MouseBiotinylated Mouse TNF-alpha (HPLC-verified), Avi Tag (Avitag?)

TNF-alpha Molecule Background

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

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