FGFR4 / CD334 Molecule
FGF R4 / CD334 Molecule Synonym Name
FGF R4 / CD334 Protein Products
|Cat No||Species||Product Description|
|FG4-H5228||Human||Human FGF R4 / CD334 Protein|
FGF R4 / CD334 Molecule Background
Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.
- (1) Eswarakumar VP, et al., 2005, Cytokine Growth Factor Rev. Apr;16(2):139-49.
- (2) Wang J, et al., 2004, Clin Cancer Res. Sep 15;10(18 Pt 1):6169-78.